Dosimetric Evaluation of 153Sm-Edtmp, 177Lu-Edtmp and 166Ho-Edtmp for Systemic Radiation Therapy: Influence of Type and Energy of Radiation and Half-Life of Radionuclides Publisher



Ranjbar H¹ ; Ghannadimaragheh M¹ ; Bahramisamani A¹ ; Beiki D² Show Affiliations
Source: Radiation Physics and Chemistry Published:2015

Abstract

In radiopharmaceutical therapy, delivered doses to critical organs must be below a certain threshold therefore internal radiation dosimetry of radiopharmaceuticals is essential. Advantages and disadvantages of radionuclides with different characteristics were evaluated for selection of appropriate radionuclide. The Monte Carlo MCNPX simulation program was used to obtain radial dose and cumulative dose of 153Sm, 177Lu and 166Ho used in radiotherapy of bone metastases. A cylindrical geometry with constant density materials was supposed for simulation of femur bone. The radius of bone marrow, bone, and surrounding soft tissue was considered 0.6cm, 1.3cm and 4cm, respectively. It was assumed that the radionuclides were uniformly distributed throughout the tumor. continuous energy spectrum of beta particle was used instead of mean beta energy. Our simulations show that absorbed dose in target organ (bone) is greater than other organs and 166Ho gives a higher dose to the critical organ of bone marrow than either 153Sm or 177Lu. Absorbed dose versus time demonstrate faster dose delivery for the short half-life radionuclides (153Sm and 166Ho). These results are in good agreement with clinical observations which show a pain relief within 1 week after intravenous administration of 153Sm-EDTMP, whereas it occurs within 2 week in the case of 177Lu-EDTMP. According to the results, combination of different radionuclides with different characteristics such as 153Sm-EDTMP and 177Lu-EDTMP could be more advantageous to patients with painful bone metastasis. © 2014 Elsevier Ltd.