Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Beta-Carotene/Cyclodextrin-Based Inclusion Complex: Improved Loading, Solubility, Stability, and Cytotoxicity Publisher



Yazdani M1, 2 ; Tavakoli O2 ; Khoobi M3, 4 ; Wu YS5 ; Faramarzi MA6 ; Gholibegloo E3 ; Farkhondeh S3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Mechanical Engineering Department, School of Computing and Engineering, University of Missouri-Kansas City, Kansas City, 64110, MO, United States
  2. 2. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, 14176, Iran
  3. 3. Biomaterials Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  4. 4. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176-53955, Iran
  5. 5. Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, 27599, NC, United States
  6. 6. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, 14174, Iran

Source: Journal of Inclusion Phenomena and Macrocyclic Chemistry Published:2022


Abstract

Beta-carotene (BC) is a vitamin A precursor and has potential anticancer benefits, but the delivery of BC is hindered by its low solubility and storage instability. To overcome these challenges, this study investigated the use of fabricated cyclodextrin-based nanosponges (CDNS) using different ratios of two cross-linkers, epiclon (EPI) and hexamethylene diisocyanate (HMDI) to form inclusion complex with BC. The ratios of crosslinkers to βCD for two most optimaly encapsulated CDNSs-BC were determined to be 2:1 for EPI and 4:1 for HMDI with loading efficiency of 61.46% and 59.61%, respectively. The charachterization tests were carefully done for two optimal CDNSs. Encapsulation significantly improved the solubility by ~ 10 folds, 30-day storage stability by 40% compared to BCs. The in vitro release of the two encapsulated products showed no burst release. The MTT assay revealed a variable increase in cytotoxic effect in both normal and cancer cells compared to free BC. Overall, the CDNSs appear to be promising carriers for the delivery of BCs. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.
Related Docs
1. Improved Curcumin Loading, Release, Solubility and Toxicity by Tuning the Molar Ratio of Cross-Linker to Β-Cyclodextrin, Carbohydrate Polymers (2019)
2. Folic Acid Decorated Magnetic Nanosponge: An Efficient Nanosystem for Targeted Curcumin Delivery and Magnetic Resonance Imaging, Journal of Colloid and Interface Science (2019)
3. The Colorful World of Carotenoids: A Profound Insight on Therapeutics and Recent Trends in Nano Delivery Systems, Critical Reviews in Food Science and Nutrition (2022)
4. Recent Progresses in the Delivery of Β-Carotene: From Nano/Microencapsulation to Bioaccessibility, Advances in Colloid and Interface Science (2022)
5. Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1, Nanomedicine (2018)
Experts (# of related papers)
View all Related Experts
Mehdi Khoobi (2)
Rassoul Dinarvand (1)