High Frequency of Braf V600e Mutation in Iranian Population Ameloblastomas

High Frequency of Braf V600e Mutation in Iranian Population Ameloblastomas Publisher Pubmed

Derakhshan S¹ ; Aminishakib P¹ ; Karimi A² ; Saffar H³ ; Abdollahi A⁴ ; Mohammadpour H⁵ ; Fard MJK⁶ ; Memarha A⁷

Show Affiliations

1. Oral and Maxillofacial Pathology Department, School of Dentistry, Tehran University of Medical Sciences, Iran
2. Oral and Maxillofacial Surgery Department, School of Dentistry, Shariati Hospital, Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Iran
3. Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Iran
4. Department of Pathology, Imam Hospital Complex, Cancer institute, Tehran University of Medical Sciences, Iran
5. Iran National Tumor Bank, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran
6. Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Iran
7. School of Dentistry, Tehran University of Medical Sciences, Iran

Source: Medicina Oral Patologia Oral y Cirugia Bucal Published:2020

Abstract

Background: Ameloblastoma is a common locally invasive but slow-growing neoplasm of the jaws with an odontogenic origin. Association between BRAF V600E mutation and clinicopathologic features and behavior of ameloblastoma remains controversial. This study aimed to evaluate BRAF V600E gene mutation and expression of its related proteins with clinicopathologic parameters in conventional ameloblastoma. Material and Methods: 50 Formalin-fixed paraffin-embedded blocks were included in this study. Immunohistochem-istry was done using rabbit monoclonal BRAF V600E mutation-specific antibody VE1. Quantitative real-time polymerase chain reaction assay was used for evaluating of BRAF V600E mutation. Results: Expression of BRAF V600E antibody was Positive in 42 out of 50 cases (84%). 46 (92%) out of 50 specimens showed BRAF V600E mutation. There were 13 cases of recurrence (26%). 3 out of 4 cases with negative mutations did not show recurrence. Conclusions: We report the highest frequency (92%) of BRAF V600E mutation in ameloblastomas in the Iranian population. Although there was not a significant association between BRAF V600E-positive immunoexpression and recurrence and clinicopathologic parameters, its high frequency could emphasize its role as a therapeutic marker in the future. © Medicina Oral S. L. C.I.F. B.

Style	Citing Format
MLA	Derakhshan S, et al.. "High Frequency of Braf V600e Mutation in Iranian Population Ameloblastomas." Medicina Oral Patologia Oral y Cirugia Bucal, vol. 25, no. 4, 2020, pp. e502-e507.
APA	Derakhshan S, Aminishakib P, Karimi A, Saffar H, Abdollahi A, Mohammadpour H, Fard MJK, Memarha A (2020). High Frequency of Braf V600e Mutation in Iranian Population Ameloblastomas. Medicina Oral Patologia Oral y Cirugia Bucal, 25(4), e502-e507.
Chicago	Derakhshan S, Aminishakib P, Karimi A, Saffar H, Abdollahi A, Mohammadpour H, Fard MJK, Memarha A. "High Frequency of Braf V600e Mutation in Iranian Population Ameloblastomas." Medicina Oral Patologia Oral y Cirugia Bucal 25, no. 4 (2020): e502-e507.
Harvard	Derakhshan S et al. (2020) 'High Frequency of Braf V600e Mutation in Iranian Population Ameloblastomas', Medicina Oral Patologia Oral y Cirugia Bucal, 25(4), pp. e502-e507.
Vancouver	Derakhshan S, Aminishakib P, Karimi A, Saffar H, Abdollahi A, Mohammadpour H, et al.. High Frequency of Braf V600e Mutation in Iranian Population Ameloblastomas. Medicina Oral Patologia Oral y Cirugia Bucal. 2020;25(4):e502-e507.
BibTex	@article{ author = {Derakhshan S and Aminishakib P and Karimi A and Saffar H and Abdollahi A and Mohammadpour H and Fard MJK and Memarha A}, title = {High Frequency of Braf V600e Mutation in Iranian Population Ameloblastomas}, journal = {Medicina Oral Patologia Oral y Cirugia Bucal}, volume = {25}, number = {4}, pages = {e502-e507}, year = {2020} }
RIS	TY - JOUR AU - Derakhshan S AU - Aminishakib P AU - Karimi A AU - Saffar H AU - Abdollahi A AU - Mohammadpour H AU - Fard MJK AU - Memarha A TI - High Frequency of Braf V600e Mutation in Iranian Population Ameloblastomas JO - Medicina Oral Patologia Oral y Cirugia Bucal VL - 25 IS - 4 SP - e502 EP - e507 PY - 2020 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract