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Osmotic Demyelination Syndrome After Bone Marrow Transplantation Publisher



Yaghoubi F1 ; Babakhani D2 ; Tavakoli F3 ; Tavakoli F3
Authors
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Authors Affiliations
  1. 1. Nephrology and Kidney Transplantation Ward, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Hematology, Oncology Research Center and Stem Cell Transplantation (HORCST), Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Nephropathology Published:2022


Abstract

A 14-year-old boy with a past medical history of bone marrow transplantation (BMT) was referred to the emergency department with the loss of consciousness and seizure. On admission, the blood test indicated strict hyponatremia with hypokalemia, hypomagnesemia, hypophosphatemia, hypoglycemia, and low-serum low-density lipoprotein cholesterol (LDL-C). After six days, the patient suffered from dysarthria, dysphagia, behavioral disturbances, disorientation, and obtundation. Based on the physical examination, hyperreflexia and upward bilateral plantar reflexes were outstanding. Lumbar puncture, spiral brain CT scan, and MRI were normal. Hence, MRI repeated 2 weeks later, and the T2-weighted image indicated the bilateral symmetric hyperintense lesions in the basal ganglia. The osmotic demyelination syndrome (ODS) is a scarce and serious neurologic complication of the quick correction of chronic strict hyponatremia. © 2022 The Author(s); Published by Society of Diabetic Nephropathy Prevention.