Preparation of Silibinin Loaded Pegylatedniosomal Nanoparticles and Investigation of Its Effect on Mcf-10A Human Breast Cancer Cell Line

Preparation of Silibinin Loaded Pegylatedniosomal Nanoparticles and Investigation of Its Effect on Mcf-10A Human Breast Cancer Cell Line

Sajjadiyan SZ¹ ; Ghadernejad H² ; Milani AT³ ; Mohammadian M³ ; Abdolahpour S⁴ ; Taslimi S¹ ; Moradisardareh H⁴ ; Afrisham R⁴ ; Kooti W⁵

Show Affiliations

1. Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran
2. Medical Student, Hamadan University of Medical Sciences, Hamadan, Iran
3. Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
4. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran
5. Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: Der Pharmacia Lettre Published:2016

Abstract

Silibinin possesses a broad spectrum of biological applications such as anticancer activities; however, poor bioavailability reduces its efficacy at the tumour sites. In the current study, silibinin was encapsulated in nanoniosomal particles in the presence of polyethylene glycol and estimated its efficacy against breast cancer in vitro. Nanoniosomalsilibinin was synthesized using the reverse phase evaporation method and characterized for shape morphology, particle size, zeta potential and drug-release characterises. In the next step, MCF 10A breast cell lines were used to evaluate the rate of nanoniosomalsilibinin cytotoxicity. In these investigation, the particle size and zeta potential of the niosomal nanoparticles were calculated 322.3±17.6nm and -18.4±1.1mV, respectively. Drug loading and encapsulation efficiency were evaluated 92.8±7.3 and 14.3±1.3, respectively. The drug release study confirmed the power of nanoparticles to drug retention by 64.1± 5.9 release in a period of 34 hours. MTT assay revealed higher cytotoxic efficacy of silibininnanoniosomal particle than free silibinin on MCF 10A cell lines. Taking collectively, the present study suggests that silibinin-loaded nanoniosomes can be applied as an effective drug delivery system to cause a usefully chemopreventive response in order to the treatment of breast cancer.

Style	Citing Format
MLA	Sajjadiyan SZ, et al.. "Preparation of Silibinin Loaded Pegylatedniosomal Nanoparticles and Investigation of Its Effect on Mcf-10A Human Breast Cancer Cell Line." Der Pharmacia Lettre, vol. 8, no. 16, 2016, pp. 70-75.
APA	Sajjadiyan SZ, Ghadernejad H, Milani AT, Mohammadian M, Abdolahpour S, Taslimi S, Moradisardareh H, Afrisham R, Kooti W (2016). Preparation of Silibinin Loaded Pegylatedniosomal Nanoparticles and Investigation of Its Effect on Mcf-10A Human Breast Cancer Cell Line. Der Pharmacia Lettre, 8(16), 70-75.
Chicago	Sajjadiyan SZ, Ghadernejad H, Milani AT, Mohammadian M, Abdolahpour S, Taslimi S, Moradisardareh H, Afrisham R, Kooti W. "Preparation of Silibinin Loaded Pegylatedniosomal Nanoparticles and Investigation of Its Effect on Mcf-10A Human Breast Cancer Cell Line." Der Pharmacia Lettre 8, no. 16 (2016): 70-75.
Harvard	Sajjadiyan SZ et al. (2016) 'Preparation of Silibinin Loaded Pegylatedniosomal Nanoparticles and Investigation of Its Effect on Mcf-10A Human Breast Cancer Cell Line', Der Pharmacia Lettre, 8(16), pp. 70-75.
Vancouver	Sajjadiyan SZ, Ghadernejad H, Milani AT, Mohammadian M, Abdolahpour S, Taslimi S, et al.. Preparation of Silibinin Loaded Pegylatedniosomal Nanoparticles and Investigation of Its Effect on Mcf-10A Human Breast Cancer Cell Line. Der Pharmacia Lettre. 2016;8(16):70-75.
BibTex	@article{ author = {Sajjadiyan SZ and Ghadernejad H and Milani AT and Mohammadian M and Abdolahpour S and Taslimi S and Moradisardareh H and Afrisham R and Kooti W}, title = {Preparation of Silibinin Loaded Pegylatedniosomal Nanoparticles and Investigation of Its Effect on Mcf-10A Human Breast Cancer Cell Line}, journal = {Der Pharmacia Lettre}, volume = {8}, number = {16}, pages = {70-75}, year = {2016} }
RIS	TY - JOUR AU - Sajjadiyan SZ AU - Ghadernejad H AU - Milani AT AU - Mohammadian M AU - Abdolahpour S AU - Taslimi S AU - Moradisardareh H AU - Afrisham R AU - Kooti W TI - Preparation of Silibinin Loaded Pegylatedniosomal Nanoparticles and Investigation of Its Effect on Mcf-10A Human Breast Cancer Cell Line JO - Der Pharmacia Lettre VL - 8 IS - 16 SP - 70 EP - 75 PY - 2016 ER -

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