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Arsenic and Weight Loss: At a Crossroad Between Lipogenesis and Lipolysis Publisher Pubmed



Handali S1 ; Rezaei M2
Authors
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Authors Affiliations
  1. 1. Medical Biomaterial Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Journal of Trace Elements in Medicine and Biology Published:2021


Abstract

Arsenic is found in soil, food, water and earth crust. Arsenic exposure is associated with chronic diseases such as cancer, cardiovascular disease as well as diabetes. One of complex effects of arsenic is on weight gain or loss. Involvement of arsenic in both weight loss and gain signaling pathways has previously been reported; however, too little attention has been paid to its weight reducing effect. Animal studies exhibited a role of arsenic in weight loss. In this regard, arsenic interference with endocrine system, leptin and adiponectin hormones as well as thermogenesis is more evidence. Apparently, arsenic-induced weight lossis generally meditated by its interaction with thermogenesis. In this review we have discussed the irregularities in metabolic pathways induced by arsenic that can lead to weight loss. © 2021 Elsevier GmbH
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