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Surfactant Administration in Preterm Neonates Using Laryngeal Mask Airway: A Randomized Clinical Trial Publisher



Amini E1 ; Sheikh M1 ; Shariat M1 ; Dalili H2 ; Azadi N1 ; Nourollahi S2
Authors
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Authors Affiliations
  1. 1. Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Acta Medica Iranica Published:2019


Abstract

In this study, we aimed to compare the efficacy of laryngeal mask airway (LMA) versus endotracheal tube in the early rescue surfactant administration in premature neonates with respiratory distress syndrome (RDS). This randomized, clinical trial evaluated 60 premature neonates with RDS. Numbered envelopes randomly assigned 30 neonates to the intervention group to receive 2.5 ml/kg/dose surfactant (Curosurf) via LMA and 30 to the control group to receive 2.5 ml/kg/dose surfactant via an endotracheal tube using the INSURE technique, exclusively during the first two hours of life. There were no differences in the requirement for mechanical ventilation (23.3% vs. 20%, P=0.75), requirement for second dose surfactant (13.3% vs. 6.7%, P=0.67), bronchopulmonary dysplasia (13.3% vs. 6.7%, P=0.67), pneumothorax (6.7% vs. 0%, P=0.49), and intraventricular hemorrhage (10% vs. 10%, P=1) between neonates who received surfactant via LMA versus those who received surfactant via endotracheal tube. LMA seems to be an effective and less invasive alternative to endotracheal intubation for surfactant delivery in premature neonates with RDS. © 2019 Tehran University of Medical Sciences. All rights reserved.