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A Longitudinal Point Prevalence Survey of Antimicrobial Use and Resistance in Tertiary Care Hospitals in Kerman: Results From the National Iranian Multicenter Point Prevalence Survey of Antimicrobials in 2021 Publisher Pubmed



Hosseininasab A1 ; Barshan F2 ; Farsiu N3 ; Nakhaie M1, 3 ; Soltani J4 ; Versporten A5 ; Goossens H5 ; Pauwels I5 ; Esfandiarpour A7
Authors
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Authors Affiliations
  1. 1. Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Science, Kerman, Iran
  2. 2. Department of Pediatric, School of Medicine, Afzalipour Hospital, Kerman University of Medical Science, Kerman, Iran
  3. 3. Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Science, Kerman, Iran
  4. 4. Department of Paediatrics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Laboratory of Medical Microbiology, Vaccine & amp
  6. 6. Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium
  7. 7. Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Infectious Diseases Published:2024


Abstract

Background: The Global Point Prevalence Survey (PPS) of antimicrobial consumption and resistance has been widely undertaken to combat the global threat of antimicrobial resistance (AMR). This study was conducted in alignment with the Global-PPS in three tertiary care hospitals in Kerman, Iran, to evaluate antimicrobial consumption patterns. Methods: The study was conducted from January 2020 to January 2021 in Afzalipour, Shafa, and Shahid Bahonar Hospitals. Data were collected using the standardized Global-PPS method at three different points throughout the year to minimize bias. Information on antimicrobial prescriptions, primary diagnosis, prophylaxis, therapy indications, and treatment type were documented. Antimicrobial prevalence was calculated using the total number of admitted patients as the denominator and those on antimicrobial regimens as the numerator. Results: The point prevalence of antimicrobial consumption in adult wards was 65.6% in Afzalipour Hospital, 42.3% in Shafa Hospital, and 78.7% in Bahonar Hospital. Non-penicillin beta-lactams, macrolides, lincosamides, and streptogramins were the most frequently prescribed antibiotic classes. Approximately 80% of prescriptions had explicit reasons documented, and targeted antibiotic therapy rates varied between 7.7% and 44.8% across hospitals. Conclusions: Antimicrobial consumption in Kerman’s tertiary care hospitals exceeded national and global levels, indicating an urgent need for interventions to promote rational antibiotic use. Infection control committees must implement rigorous monitoring measures to reduce antimicrobial resistance. Ongoing surveillance and targeted interventions are essential to curb the rising rates of antimicrobial resistance in the region. © The Author(s) 2024.
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