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Effect of Exercise and Morphine on Psychological and Physical Dependencies, Bdnf and Trkb Gene Expression in Rat’S Hippocampus Publisher



Naghshvarian M1 ; Zarrindast MR1 ; Mehr SE1 ; Ommati MM2 ; Sajjadi SF3
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Animal Sciences, School of Agriculture, Shiraz University, Shiraz, Iran
  3. 3. Department of Psychology, University of Otago, Dunedin, New Zealand

Source: Pakistan Journal of Medical Sciences Published:2017


Abstract

Objectives: To compare the effect of exercise and morphine on abstinence syndrome and hippocampal gene expression in rat model. Methods: Thirty adult male rats were exposed to voluntary wheel exercise (low, medium, high) for 28 days. The subjects entered Conditioned Place Preference (CPP) apparatus and experienced morphine (low, medium, high) CPP and followed by naloxone test. Correlation between exercise level, morphine injection, concurrent morphine administration and exercise with morphine CPP, BDNF and TrkB genes was determined. Rats were euthanized, decapitated and the hippocampus was removed. The expression of BDNF and TrkB genes were evaluated by real time PCR. Results: Active rats ran an average of 839.18 m/d. A significant (P<0.001) correlation between exercise level, morphine injection, concurrent morphine administration and exercise with morphine CPP and BDNF and TrKB gene expressions was found. Conclusion: Voluntary exercise in different levels potentiates the brain rewarding system, CPP scale, and hippocampal BDNF and TrKB expressions. High range of voluntary exercise demonstrated an increase in the likelihood of developing addictive and drug-seeking behavior. © 2017, Professional Medical Publications. All rights reserved.
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