The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency

The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency Publisher Pubmed

Bagheri Y^{1, 2, 3} ; Sanaei R^{4, 5} ; Yazdani R² ; Shekarabi M^{3, 4} ; Falak R^{3, 4} ; Mohammadi J⁶ ; Abolhassani H^{2, 7} ; Aghamohammadi A²

Source: International Archives of Allergy and Immunology Published:2019

Abstract

Selective immunoglobulin A deficiency (SIgAD) is the most prevalent type of primary immunodeficiency disorder. The phenotypic feature of SIgAD is related to a defect in B lymphocyte differentiation into plasma cell-producing immunoglobulin A (IgA). In this review, we summarize the recent advances in this regard. Genetic (including major histocompatibility complex [MHC] and non-MHC genes), immunologic (including B and T lymphocyte subsets abnormality), cytokines/chemokines and their related receptors, apoptosis and microbiota defects are reviewed. The mechanisms leading to SIgAD are most likely multifactorial and it can be speculated that several pathways controlling B cells functions or regulating epigenetic of the IGHA gene encoding constant region of IgA heavy chain and long-term survival of IgA switched memory B cells and plasma cells may be defective in different SIgAD patients. © 2019 S. Karger AG, Basel.

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Style	Citing Format
MLA	Bagheri Y, et al.. "The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency." International Archives of Allergy and Immunology, vol. 179, no. 3, 2019, pp. 231-245.
APA	Bagheri Y, Sanaei R, Yazdani R, Shekarabi M, Falak R, Mohammadi J, Abolhassani H, Aghamohammadi A (2019). The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency. International Archives of Allergy and Immunology, 179(3), 231-245.
Chicago	Bagheri Y, Sanaei R, Yazdani R, Shekarabi M, Falak R, Mohammadi J, Abolhassani H, Aghamohammadi A. "The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency." International Archives of Allergy and Immunology 179, no. 3 (2019): 231-245.
Harvard	Bagheri Y et al. (2019) 'The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency', International Archives of Allergy and Immunology, 179(3), pp. 231-245.
Vancouver	Bagheri Y, Sanaei R, Yazdani R, Shekarabi M, Falak R, Mohammadi J, et al.. The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency. International Archives of Allergy and Immunology. 2019;179(3):231-245.
BibTex	@article{ author = {Bagheri Y and Sanaei R and Yazdani R and Shekarabi M and Falak R and Mohammadi J and Abolhassani H and Aghamohammadi A}, title = {The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency}, journal = {International Archives of Allergy and Immunology}, volume = {179}, number = {3}, pages = {231-245}, year = {2019} }
RIS	TY - JOUR AU - Bagheri Y AU - Sanaei R AU - Yazdani R AU - Shekarabi M AU - Falak R AU - Mohammadi J AU - Abolhassani H AU - Aghamohammadi A TI - The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency JO - International Archives of Allergy and Immunology VL - 179 IS - 3 SP - 231 EP - 245 PY - 2019 ER -

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