Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Publisher Pubmed

Taghiabadi E¹ ; Nilforoushzadeh MA¹ ; Aghdami N²

Show Affiliations

1. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Source: Skin Pharmacology and Physiology Published:2020

Abstract

The dermal papilla comprises mesenchymal cells in hair follicles, which play the main role in regulating hair growth. Maintaining the potential hair inductivity of dermal papilla cells (DPCs) and dermal sheath cells during cell culture is the main factor in in vitro morphogenesis and regeneration of hair follicles. Using common methods for the cultivation of human dermal papilla reduces the maintenance requirements of the inductive capacity of the dermal papilla and the expression of specific dermal papilla biomarkers. Optimizing culture conditions is therefore crucial for DPCs. Moreover, exosomes appear to play a key role in regulating the hair follicle growth through a paracrine mechanism and provide a functional method for treating hair loss. The present review investigated the biology of DPCs, the molecular and cell signaling mechanisms contributing to hair follicle growth in humans, the properties of the dermal papilla, and the effective techniques in maintaining hair inductivity in DPC cultures in humans as well as hair follicle bioengineering. © 2020

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Experts (# of related papers)

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Mohammad Ali Nilforoushzadeh (4)

Ehsan Taghiabadi (3)

Style	Citing Format
MLA	Taghiabadi E, Nilforoushzadeh MA, Aghdami N. "Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods." Skin Pharmacology and Physiology, vol. 33, no. 5, 2020, pp. 280-292.
APA	Taghiabadi E, Nilforoushzadeh MA, Aghdami N (2020). Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods. Skin Pharmacology and Physiology, 33(5), 280-292.
Chicago	Taghiabadi E, Nilforoushzadeh MA, Aghdami N. "Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods." Skin Pharmacology and Physiology 33, no. 5 (2020): 280-292.
Harvard	Taghiabadi E, Nilforoushzadeh MA, Aghdami N (2020) 'Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods', Skin Pharmacology and Physiology, 33(5), pp. 280-292.
Vancouver	Taghiabadi E, Nilforoushzadeh MA, Aghdami N. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods. Skin Pharmacology and Physiology. 2020;33(5):280-292.
BibTex	@article{ author = {Taghiabadi E and Nilforoushzadeh MA and Aghdami N}, title = {Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods}, journal = {Skin Pharmacology and Physiology}, volume = {33}, number = {5}, pages = {280-292}, year = {2020} }
RIS	TY - JOUR AU - Taghiabadi E AU - Nilforoushzadeh MA AU - Aghdami N TI - Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods JO - Skin Pharmacology and Physiology VL - 33 IS - 5 SP - 280 EP - 292 PY - 2020 ER -

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