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A Comparative Evaluation of Error Processing Performance and Its Relationship With Cognitive Function in Patients With Alzheimer's Disease, Individuals With Mild Cognitive Impairment, and Normal Controls Using the Event-Related Potentials Publisher



Hedayatjoo M1 ; Tehranidoost M1, 2, 3 ; Vahabi Z4, 5 ; Akbarfahimi M6 ; Khosrowabadi R7
Authors
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Authors Affiliations
  1. 1. Institute for Cognitive Science Studies, Tehran, Iran
  2. 2. Research Center for Cognitive and Behavioral Sciences, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Psychiatry, Faculty of Medicine, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Geriatric Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Psychiatry, Cognitive Neurology and Neuropsychiatry Division, Faculty of Medicine, Roozbeh Hospital, Tehran University of Medical Science, Tehran, Iran
  6. 6. Department of Occupational Therapy, School of Rehabilitation Sciences, Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran

Source: Journal of Alzheimer's Disease Reports Published:2024


Abstract

Background: Some pathological changes occur in patients with Alzheimer's disease (AD) prior to the onset of clinical symptoms. Objective: In the present study, we aimed to investigate the potential of event-related potential (ERP) components in error processing performance as a neuromarker of mild cognitive impairment (MCI) and transition to AD and their relation with cognitive functions. Methods: We conducted an evaluation of 16 patients diagnosed with AD, 16 patients with MCI, and 15 normal controls using three subtests from the Cambridge Neuropsychological Testing Automated Battery (CANTAB). The ERP components of error processing were extracted and compared among the three groups using a modified version of the Eriksen flanker task. Additionally, we assessed the correlation between the cognitive results and the ERP components. Results: Significant differences were observed among the three groups in terms of providing correct responses following errors and the amplitude of error-related negativity (ERN). These differences were also significant between all paired groups. Regarding other ERP components of error processing and the peak latency of ERN, no significant differences were observed among the three groups. The findings revealed that the spatial working memory and new learning were correlated with the amplitude of ERN. Conclusions: In the context of error processing performance, both the accuracy of responses following an error and the amplitude of ERN can be considered as indicators of MCI and its progression to AD. The present findings do not support the use of other error processing components as differential markers in the three groups. © 2024 - The authors. Published by IOS Press.