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Natural Killer Cell-Based Therapies in Neuroblastoma Publisher Pubmed



Ghasempour A1 ; Mohseni R1 ; Sharif PM1 ; Hamidieh AA1
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Authors Affiliations
  1. 1. Pediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellular Immunology Published:2025


Abstract

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood forming around 15 % of all pediatric tumors. Despite advances in the treatment of NB, high-risk patients still face a grave prognosis. Adoptive cell therapies based on NK cells are becoming an assistive treatment for such cases. Moreover, there is also evidence that NKT-based therapies have promising results in the management of NB. Lower complications in comparison with adoptive T cell therapies, various cell sources, and miscellaneous tumor recognition mechanisms are some of the advantages of NK- and NKT-based therapies. This review is dedicated to searching for recent advances in this field. © 2024 Elsevier Inc.
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