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Comparing the Effect of Adjunctive N-Acetylcysteine Plus Low Dose Contraceptive With Low Dose Contraceptive Alone on Recurrence of Ovarian Endometrioma and Chronic Pelvic Pain After Conservative Laparoscopic Surgery: A Randomised Clinical Trial Study Publisher Pubmed



Asgari Z1 ; Moini A1 ; Montazeri A2 ; Tavoli Z3 ; Hosseini L4 ; Hosseini R1 ; Tehranian A1 ; Karimi R1
Authors
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Authors Affiliations
  1. 1. Departments of Minimally Invasive Gynaecologic Surgery, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Health Metrics Research Centre, Institute for Health Sciences Research, ACECR, Tehran, Iran
  3. 3. Departments of Minimally Invasive Gynaecologic Surgery, Ziaeeyan Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Research Development Center, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Obstetrics and Gynaecology Published:2022


Abstract

This study aimed to compare the effectiveness of NAC plus low dose contraceptive with low dose contraceptives alone. This was a randomised trial on a sample of women who underwent conservative laparoscopic surgery for ovarian endometrioma. Patients were randomly assigned either to the NAC plus low dose contraceptive group (n = 48) or low dose contraceptive alone (n = 52). To evaluate the recurrence rate transvaginal ultrasound was performed. Pelvic pain was assessed using a visual analogue scale (VAS). All assessments were performed at two points in time: 3 and 6 months post-surgery and compared between the two regimens. The findings indicated that reduction in the recurrence rate of endometrioma and pelvic pain were similar between both groups. The findings showed that adding N-acetylcysteine to low dose contraceptive treatment has a similar effect in reducing the recurrence rate of endometrioma and pelvic pain when compared to low dose contraceptives alone.Impact statementWhat is already known on this subject? Endometriosis is a frequent benign disease-producing inflammatory response with mild to severe symptoms. Although surgical removal of ectopic lesions is the first-line intervention, the recurrence rate of the disease is high. Thus this study aimed to compare the effectiveness of N-acetylcysteine plus low dose contraceptive with low dose contraceptive alone. What do the results of this study add? The findings showed that adding N-acetylcysteine to low dose contraceptive treatment has a similar effect in reducing the recurrence rate of endometrioma and pelvic pain when compared to low dose contraceptives alone. What are the implications of these findings for clinical practice and/or further research? It is recommended to increase the duration of drug administration in future studies. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
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