Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Modulatory Role of Nicotine on Cognitive and Non-Cognitive Functions Publisher Pubmed



Zarrindast MR1, 2, 3 ; Khakpai F4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Neuroendocrinology, Endocrinology and Metabolism, Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: Brain Research Published:2019


Abstract

Nicotine, as the main component of tobacco, plays a key role in various behaviors of both humans and animals including reward, addiction, learning and memory, anxiety, pain as well as body weight and temperature. Nicotine exerts its function by activating nicotinic acetylcholine receptors (nAChRs) which one highly expressed throughout the nervous system. The mesocorticolimbic dopamine system mediates the processing of reward, learning and memory behaviors produced by nicotine. In addition, some structures of the central nervous system, such as the hippocampus and amygdala, have a major role in mediation of nicotine properties. Furthermore, the effect of nicotine in modulation of cognitive and non-cognitive functions can produce by other neurochemical systems such as opioid, dopamine, glutamate, cannabinoids, GABA and serotonin as well as nitric oxide. The present review will explain involvement of these neurotransmitters on cognitive and non-cognitive functions induced by nicotine. © 2018
Related Docs
View other Related Docs
1. State-Dependent Memory and Its Modulation by Different Brain Areas and Neurotransmitters, EXCLI Journal (2020)
2. Cholestasis and Behavioral Disorders, Gastroenterology and Hepatology from Bed to Bench (2021)
3. The Modulatory Role of Dopamine in Anxiety-Like Behavior, Archives of Iranian Medicine (2015)
4. Harmaline-Induced Amnesia: Possible Role of the Amygdala Dopaminergic System, Neuroscience (2016)
5. The Effect of Ca1 Dopaminergic System in Harmaline-Induced Amnesia, Neuroscience (2015)
6. The Role of Nmda Receptors of the Medial Septum and Dorsal Hippocampus on Memory Acquisition, Pharmacology Biochemistry and Behavior (2016)
7. Possible Interaction Between the Ventral Hippocampal Cannabinoid Cb2 and Muscarinic Acetylcholine Receptors on the Modulation of Memory Consolidation in Mice, NeuroReport (2020)
8. The Effect of Ca1 Dopaminergic System on Amnesia Induced by Harmane in Mice, Acta Neurologica Belgica (2019)
Experts (# of related papers)
View all Related Experts
Seyed Mohammad Tavangar (3)
Ahmad Reza Dehpour (2)
Other Related Docs
9. Activation of Trpv1 Receptors Affects Memory Function and Hippocampal Trpv1 and Creb Mrna Expression in a Rat Model of Biliary Cirrhosis, Neurological Research (2018)
10. Dorsal Hippocampal Cannabinergic and Gabaergic Systems Modulate Memory Consolidation in Passive Avoidance Task, Brain Research Bulletin (2018)
11. The Involvement of Medial Septum 5-Ht1 and 5-Ht2 Receptors on Acpa-Induced Memory Consolidation Deficit: Possible Role of Trpc3, Trpc6 and Trpv2, Journal of Psychopharmacology (2015)
12. Synergistic Effect Between D-Ap5 and Muscimol in the Nucleus Accumbens Shell on Memory Consolidation Deficit in Adult Male Wistar Rats: An Isobologram Analysis, Neurobiology of Learning and Memory (2017)
13. The Effect of Bla Gabaa Receptors in Anxiolytic-Like Effect and Aversive Memory Deficit Induced by Acpa, EXCLI Journal (2015)
14. Activation and Inactivation of Nicotinic Receptnors in the Dorsal Hippocampal Region Restored Negative Effects of Total (Tsd) and Rem Sleep Deprivation (Rsd) on Memory Acquisition, Locomotor Activity and Pain Perception, Neuroscience (2020)
15. Modulatory Effects of the Basolateral Amygdala Α2-Adrenoceptors on Nicotine-Induced Anxiogenic-Like Behaviours of Rats in the Elevated Plus Maze, Neuropharmacology (2016)
16. Possible Involvement of the Ca1 Gabaergic System on Harmaline Induced Memory Consolidation Deficit, Brain Research Bulletin (2017)
17. Effect of Pretreatment With Intracerebroventricular Injection of Minocycline on Morphine-Induced Memory Impairment in Passive Avoidance Test: Role of P-Creb and C-Fos Expression in the Dorsal Hippocampus and Basolateral Amygdala Regions, Clinical and Experimental Pharmacology and Physiology (2019)
18. The Modulatory Effect of Ca1 Gabab Receptors on Ketamine-Induced Spatial and Non-Spatial Novelty Detection Deficits With Respect to Ca2+, Neuroscience (2015)
19. Investigating the Role of P-Creb and C-Fos Protein Expression in Nicotine-Induced Anxiogenesis in Rats, Journal of Babol University of Medical Sciences (2020)
20. Role of Ca1 Gabaa and Gabab Receptors on Learning Deficit Induced by D-Ap5 in Passive Avoidance Step-Through Task, Brain Research (2018)
21. The Effect of 5-Ht4 Serotonin Receptors in the Ca3 Hippocampal Region on D-Ap5-Induced Anxiolytic-Like Effects: Isobolographic Analyses, Behavioural Brain Research (2021)
22. Additive Effect of Bla Gabaa Receptor Mechanism and (+)-Mk-801 on Memory Retention Deficit, an Isobologram Analysis, Pharmacology Biochemistry and Behavior (2016)
23. The Effect of Microinjection of Cart 55-102 Into the Nucleus Accumbens Shell on Morphine-Induced Conditioned Place Preference in Rats: Involvement of the Nmda Receptor, Peptides (2020)
24. Influence of Morphine on Medial Prefrontal Cortex Alpha2 Adrenergic System in Passive Avoidance Learning in Rats, Pharmacology Biochemistry and Behavior (2015)
25. Effect of Nucleus Accumbens Shell 5-Ht4 Receptors on the Impairment of Acpa-Induced Emotional Memory Consolidation in Male Wistar Rats, Behavioural Pharmacology (2016)
26. The Hippocampal Nmda Receptors May Be Involved in Acquisition, But Not Expression of Acpa-Induced Place Preference, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2015)
27. Evidence for the Involvement of Nmda Receptors in the Antidepressant-Like Effect of Nicotine in Mouse Forced Swimming and Tail Suspension Tests, Psychopharmacology (2015)
28. The Protective Effects of Nicotine and Bucladesine on Impaired Avoidance Memory Caused by Sodium Arsenate Toxicity in Mice, Iranian Journal of Toxicology (2021)
29. Activation and Deactivation of 5-Ht1 Receptor of Accumbens Shell Area Does Not Alter Acpa-Induced Aversive Memory Deficit in Male Rat, Archives of Iranian Medicine (2017)
30. 5-Ht1a Receptor Blockade Targeting the Basolateral Amygdala Improved Stress-Induced Impairment of Memory Consolidation and Retrieval in Rats, Neuroscience (2015)
31. Interaction Between Harmane, a Class of Β-Carboline Alkaloids, and the Ca1 Serotonergic System in Modulation of Memory Acquisition, Neuroscience Research (2017)
32. The Effects of Ca1 5Ht4 Receptors in Mk801-Induced Amnesia and Hyperlocomotion, Neuroscience Letters (2015)
33. Possible Involvement of the Ca1 Gabaa Receptors Upon Acquisition and Expression of the Acpa-Induced Place Preference in Mice, Physiology and Behavior (2016)
34. Assessment of Increase in Citrate and Kcl Consumption and Probable Underlying Mechanisms in Morphine-Dependent Socially Isolated Rats, Physiology and Pharmacology (2016)
35. The Effect of Nicotine on Antidepressant and Anxiolytic Responses Induced by Citalopram and Citicoline in Mice, Acta Neurobiologiae Experimentalis (2023)
36. The Effects of Intra-Dorsal Hippocampus Infusion of Pregnenolone Sulfate on Memory Function and Hippocampal Bdnf Mrna Expression of Biliary Cirrhosis-Induced Memory Impairment in Rats, Neuroscience (2015)
37. Additive Effect of Harmane and Muscimol for Memory Consolidation Impairment in Inhibitory Avoidance Task, Neuroscience (2016)
38. Role of Dorsal Hippocampal Orexin-1 Receptors in Memory Restoration Induced by Morphine Sensitization Phenomenon, Neuroscience (2016)
39. Μ-Opioid Receptor in the Ca1 Involves in Tramadol and Morphine Cross State-Dependent Memory, Neuroscience Letters (2019)
40. The Effect of Fish Oil on Social Interaction Memory in Total Sleep-Deprived Rats With Respect to the Hippocampal Level of Stathmin, Tfeb, Synaptophysin and Lamp-1 Proteins, Prostaglandins Leukotrienes and Essential Fatty Acids (2020)