Internal Dosimetry of 64Cu-Dox-Loaded Microcapsules by Monte Carlo Method

Internal Dosimetry of 64Cu-Dox-Loaded Microcapsules by Monte Carlo Method Publisher Pubmed

Heidari S¹ ; Sadeghi M¹ ; Akhlaghi M² ; Beiki D² ; Yazdi SI³

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1. Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2. Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Medical Radiation Engineering Department, Science and Research Branch, Islamic Azad University, Tehran, Iran

Source: Applied Radiation and Isotopes Published:2023

Abstract

Some of the issues regarding introducing new radiocompounds in nuclear medicine are the distribution patterns, delivered dose to different organs, diagnostic abilities and side effects. In this study, in order to assess the biodistribution of 64Cu-DOX-loaded microcapsules, rats were IV-injected with the microcapsules, and 1, 4, 14, and 24 h later, the activities of the targeted organs were measured (%ID/g). The accumulated activities were achieved by %ID/g curves, and S-factors were obtained by MCNP outputs. The MIRD formulation and Monte Carlo method were used to determine the absorbed dose in the target organs. The biodistribution data and PET-CT images showed that the lungs were where the majority of activity was seen. According to MIRD and MCNP, the maximum dose delivered in the lungs was 5.79E+01 mGy/MBq and 4.70E+01 mGy/MBq, respectively. Also, the effective dose was 1.2E+01 for MIRD and 8.31E+00 mSv/MBq for MCNP. These results indicate that 64Cu-DOX microcapsules can be considered a new radiocompound in pulmonary imaging, and MCNP simulation can be a reliable method for internal dosimetry. © 2023

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Experts (# of related papers)

Nasim Vahidfar (1)

Saeed Farzanefar (1)

Style	Citing Format
MLA	Heidari S, et al.. "Internal Dosimetry of 64Cu-Dox-Loaded Microcapsules by Monte Carlo Method." Applied Radiation and Isotopes, vol. 196, no. , 2023, pp. -.
APA	Heidari S, Sadeghi M, Akhlaghi M, Beiki D, Yazdi SI (2023). Internal Dosimetry of 64Cu-Dox-Loaded Microcapsules by Monte Carlo Method. Applied Radiation and Isotopes, 196(), -.
Chicago	Heidari S, Sadeghi M, Akhlaghi M, Beiki D, Yazdi SI. "Internal Dosimetry of 64Cu-Dox-Loaded Microcapsules by Monte Carlo Method." Applied Radiation and Isotopes 196, no. (2023): -.
Harvard	Heidari S et al. (2023) 'Internal Dosimetry of 64Cu-Dox-Loaded Microcapsules by Monte Carlo Method', Applied Radiation and Isotopes, 196(), pp. -.
Vancouver	Heidari S, Sadeghi M, Akhlaghi M, Beiki D, Yazdi SI. Internal Dosimetry of 64Cu-Dox-Loaded Microcapsules by Monte Carlo Method. Applied Radiation and Isotopes. 2023;196():-.
BibTex	@article{ author = {Heidari S and Sadeghi M and Akhlaghi M and Beiki D and Yazdi SI}, title = {Internal Dosimetry of 64Cu-Dox-Loaded Microcapsules by Monte Carlo Method}, journal = {Applied Radiation and Isotopes}, volume = {196}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Heidari S AU - Sadeghi M AU - Akhlaghi M AU - Beiki D AU - Yazdi SI TI - Internal Dosimetry of 64Cu-Dox-Loaded Microcapsules by Monte Carlo Method JO - Applied Radiation and Isotopes VL - 196 IS - SP - EP - PY - 2023 ER -

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