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The Earliest Report of Smallpox Oral Vaccination by Baha’ Al-Dawlah Razi in the 16Th Century Publisher Pubmed



Arabian S1, 2 ; Sadr M3 ; Ayati MH1, 4 ; Ince F5 ; Zargaran A1
Authors
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Authors Affiliations
  1. 1. Department of History of Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Scientific Student Association of History of Medicine, Pharmacy, and Veterinary, Student Scientific Researcher Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of History of Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Guest Professor, Beijing University of Chinese Medicine, Beijing, China
  5. 5. Department of History of Medicine and Ethics, Faculty of Medicine, Suleyman Demirel University, Isparta

Source: Vaccine Published:2025


Abstract

Smallpox is one of the viral and contagious diseases that were always talked about and deadly epidemics that killed many people for many centuries. Through the analysis of historical and textual material, this paper seeks to investigate the smallpox eradication process. It starts with a brief history of smallpox before listing the common methods of eradicating the illness throughout the 16th century. There was a type of traditional oral smallpox vaccination, reported by Baha’ al-Dawlah Razi, a Persian physician in his book, Khulasat al-Tajarib (The Summary of Experiences). This method could be considered the earliest remained report of practical solution to prevent smallpox; at least 3 centuries earlies than smallpox vaccination by Edward Jenner. © 2025
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