Glycosylated Gadolinium As Potential Metabolic Contrast Agent Vs Gd-Dtpa for Metabolism of Tumor Tissue in Magnetic Resonance Imaging

Glycosylated Gadolinium As Potential Metabolic Contrast Agent Vs Gd-Dtpa for Metabolism of Tumor Tissue in Magnetic Resonance Imaging Publisher

Heydarnezhadi S¹ ; Riahi Alam N¹ ; Haghgoo S² ; Ghanaati H³ ; Khoobi M⁴ ; Gorji E² ; Rafiei B³ ; Nikfar B¹ ; Amirrashedi M¹

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1. Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences (TUMS), Keshavaz blvd, 16 Azar St, Tehran, 14145, Iran
2. Pharmaceutical Department, Food and Drug Laboratory Research Center, Food and Drug Organization (FDO), Ministry of Health, Imam St., Valiasre Cross, Tehran, 1113615911, Iran
3. Medical Imaging Center, Imam Hospital Complex, School of Medicine, Tehran University of Medical Sciences (TUMS), Keshavaz Blvd., Tehran, 1419733141, Iran
4. Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran

Source: Applied Magnetic Resonance Published:2016

Abstract

Modern imaging technologies such as mMRI employ contrast agents to visualize the tumor microenvironment; therefore, demand for contrast agents, with an enhanced sensitivity and tissue tumor-specific target, is very high. The purpose of this study synthesizes novel metabolic contrast agent (Gd-DTPA-DG) and evaluates accumulation in tumor tissue for early diagnostic cancer. The contrast agent was synthesized and characterized with using different techniques including dynamic light scattering, high resolution transmission electron microscopy, Fourier transform infrared spectroscopy and inductively coupled plasma atomic emission spectroscopy (ICP-AES). Finally, MRI imaging performed to determine in vitro and in vivo relaxometry. Gd-DTPA-DG was specifically investigated in tissue tumor over a 45 min in vivo because of its ability to target metabolically active tumor tissue, and comparison with conventional contrast agent [Gd-DTPA (Magnevist, Bayer-USA)]. According to the result, the maximum image signal intensity in different concentrations (0.02 to approximately 0.8 mM), longitudinal relaxation time (T1) and transverse relaxation time (T2) were obtained. Signal intensity of tumor tissue was shown at 15 and 30 min after injection reaches maximum for Gd-DTPA-DG and Gd-DTPA (Magnevist, Bayer-USA), respectively. But Gd-DTPA-DG shown signal intensity higher of Gd-DTPA (Magnevist, Bayer-USA) over 45 min, comparison with Gd-DTPA (Magnevist, Bayer-USA). Images showed metabolic contrast agent penetrate into cells and accumulated in tumor. These results showed that the novel metabolic contrast agent could become a useful tool in early detection of cancer. © 2016, Springer-Verlag Wien.

Style	Citing Format
MLA	Heydarnezhadi S, et al.. "Glycosylated Gadolinium As Potential Metabolic Contrast Agent Vs Gd-Dtpa for Metabolism of Tumor Tissue in Magnetic Resonance Imaging." Applied Magnetic Resonance, vol. 47, no. 4, 2016, pp. 375-385.
APA	Heydarnezhadi S, Riahi Alam N, Haghgoo S, Ghanaati H, Khoobi M, Gorji E, Rafiei B, Nikfar B, Amirrashedi M (2016). Glycosylated Gadolinium As Potential Metabolic Contrast Agent Vs Gd-Dtpa for Metabolism of Tumor Tissue in Magnetic Resonance Imaging. Applied Magnetic Resonance, 47(4), 375-385.
Chicago	Heydarnezhadi S, Riahi Alam N, Haghgoo S, Ghanaati H, Khoobi M, Gorji E, Rafiei B, Nikfar B, Amirrashedi M. "Glycosylated Gadolinium As Potential Metabolic Contrast Agent Vs Gd-Dtpa for Metabolism of Tumor Tissue in Magnetic Resonance Imaging." Applied Magnetic Resonance 47, no. 4 (2016): 375-385.
Harvard	Heydarnezhadi S et al. (2016) 'Glycosylated Gadolinium As Potential Metabolic Contrast Agent Vs Gd-Dtpa for Metabolism of Tumor Tissue in Magnetic Resonance Imaging', Applied Magnetic Resonance, 47(4), pp. 375-385.
Vancouver	Heydarnezhadi S, Riahi Alam N, Haghgoo S, Ghanaati H, Khoobi M, Gorji E, et al.. Glycosylated Gadolinium As Potential Metabolic Contrast Agent Vs Gd-Dtpa for Metabolism of Tumor Tissue in Magnetic Resonance Imaging. Applied Magnetic Resonance. 2016;47(4):375-385.
BibTex	@article{ author = {Heydarnezhadi S and Riahi Alam N and Haghgoo S and Ghanaati H and Khoobi M and Gorji E and Rafiei B and Nikfar B and Amirrashedi M}, title = {Glycosylated Gadolinium As Potential Metabolic Contrast Agent Vs Gd-Dtpa for Metabolism of Tumor Tissue in Magnetic Resonance Imaging}, journal = {Applied Magnetic Resonance}, volume = {47}, number = {4}, pages = {375-385}, year = {2016} }
RIS	TY - JOUR AU - Heydarnezhadi S AU - Riahi Alam N AU - Haghgoo S AU - Ghanaati H AU - Khoobi M AU - Gorji E AU - Rafiei B AU - Nikfar B AU - Amirrashedi M TI - Glycosylated Gadolinium As Potential Metabolic Contrast Agent Vs Gd-Dtpa for Metabolism of Tumor Tissue in Magnetic Resonance Imaging JO - Applied Magnetic Resonance VL - 47 IS - 4 SP - 375 EP - 385 PY - 2016 ER -

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