Advanced Microbial Bioremediation Techniques for Heavy Metal Detoxification and Environmental Restoration Publisher



Zabet A H ; Mohsenzadeh A ; Kamali K ; Ahmady Asbchin S
Source: Open Microbiology Journal Published:2026

Abstract

Heavy metals contaminate ecosystems, posing significant risks to human and animal health in the modern environment. Understanding heavy metal accumulation sources is essential to reducing their negative consequences. This article navigates through the complexities of heavy metal pollution, shedding light on its sources and mechanisms of dispersion. Heavy metals from industrial, agricultural, and urban activities build up in soil, water, and air. They remain continuously bioaccumulated in living species, causing toxicity and ecological imbalance. Heavy metals can cause an increase in antibiotic-resistant microorganisms, which, in turn, leads to an increase in antimicrobial resistance. Despite these severe hurdles, biosorption approaches offer a potential solution. The work further highlights the potential of biosorption as a sustainable remediation strategy, utilizing bacteria, fungi, and algae to effectively remove heavy metals from contaminated environments. Bacteria play a crucial role in biosorption because they biosorb heavy metals through multiple mechanisms, including cell-wall binding of metal ions, Extracellular Polymeric Substance (EPS) complexation, and metal sequestration within structured biofilm matrices, each contributing to efficient metal removal from contaminated environments. Additionally, the study further explores the use of microbial bioremediation through genetic engineering, which offers the potential to enhance metal-binding capacity and environmental tolerance in microorganisms. The article concludes with an urgent call for integrated, biotechnology-driven strategies to mitigate heavy metal pollution, emphasizing that judicious use of both natural and engineered microbial systems can restore ecological stability, reduce public health hazards, and contribute to the long-term management and protection of the environment. By exploring the complex interactions between heavy metals and microbial communities and applying advanced bioremediation technologies, we can move toward restoring ecological balance and ensuring a healthier future for generations to come. © 2026 The Author(s). Published by Bentham Open., 2026.