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The Association of Lrp5 (Rs556442) Polymorphism With Body Composition and Obesity in Postmenopausal Women Publisher Pubmed



Adabi E1 ; Omidfar A2 ; Farahani NA3 ; Faghihi F4 ; Asghar Malek Hosseini SA5 ; Maghbooli Z6 ; Shirvani A7
Authors
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Authors Affiliations
  1. 1. Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Islamic Azad University, Ashkezar Branch, Yazd, Iran
  4. 4. Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
  5. 5. Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran
  6. 6. Multiple Sclerosis Research Center, Neurosciences Institute of Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, United States

Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2019


Abstract

Aim: The main of this study was to investigate the association between the rs566442 (V1119V) coding polymorphism of Low-density lipoprotein receptor-related protein 5 (LRP5) with obesity and basal metabolic rate in Iranian postmenopausal women. Methods: This cross-sectional study was performed on 350 postmenopausal women with a mean age of 57.8 years (SD ± 6.14). Body composition was analyzed by bioelectrical impedance analysis (BIA) resistance. Obesity was defined based on Body mass index (BMI) ≥30 kg/m2. To determine the genotype of SNP (rs556442), PCR-RFLP assay was performed and confirmed by sequencing. DNA samples from participants were genotyped using the RFLP-PCR method. Results: Among the study population 37.1% (130) were obese. G allele had minor-allele frequency of 0.38% in our population. The frequency of genotypes in our study population was 12.9% (45 person) GG, 35.7% (125 person) AA and 51.4% (180) GA. After adjusting age and menopausal age, only basal metabolic rate showed significantly higher in GG group compare to other groups (p = 0.02). Our data showed basal metabolic rate was higher in obese women with GG genotype in comparison to obese women with AG and AA genotypes. Discussion: The findings of this study suggest that the GG genotype of SNP (rs556442) could protective role in obese women through the association with BMR. © 2019
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