Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Vascular Endothelial Growth Factor in Serum and Saliva of Oral Lichen Planus and Oral Squamous Cell Carcinoma Patients



Aghahosseini F1 ; Mirzaiidizgah I2 ; Mohebbian M3 ; Sarookani MR4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Dental Research Center, Dental Research Institute, Tehran University of Medical Sciences & Department of Oral and Maxillo facial Medicine, Faculty of Dentistry, The Academy of Medical Sciences, Tehran, Iran
  2. 2. Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran
  3. 3. Oral and Maxillo facial Medicine, Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
  4. 4. Cell and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

Source: Journal of Kerman University of Medical Sciences Published:2018

Abstract

Background: Oral lichen planus (OLP) is considered as a potentially malignant disorder and vascular endothelial growth factor (VEGF) may play a key role in cancer development. The aim of this study was to compare serum and saliva VEGF among patients with OLP, oral squamous cell carcinoma (OSCC) and a healthy control group. Methods: A cross sectional study was performed on 27 patients with OLP, 27 patients with OSCC and 27 healthy volunteers. The serum and saliva VEGF were assayed by ELISA method. Statistical analysis of ANOVA was used. Results: The mean saliva flow rate and serum VEGF in OLP and OSCC patients were significantly lower compared to healthy control group (p<0.05), but there was no significant difference between OLP and OSCC patients. There was no significant difference in mean salivary VEGF among groups. Conclusion: It seems that saliva VEGF may not be a good biomarker for OLP and OSCC. © 2018, Kerman University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. Muscarinic Cholinergic Receptors (Mr3) in Saliva of Patients With Oral Lichen Planus, Archives of Dermatological Research (2016)
2. Comparative Evaluation of Egf in Oral Lichen Planus and Oral Squamous Cell Carcinoma, Acta Medica Iranica (2015)
3. Evaluation of Potential Risk Factors That Contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review, Journal of Contemporary Dental Practice (2016)
4. Serum and Saliva Mmp-3 in Patients With Olp and Oral Scc, Journal of Contemporary Dental Practice (2015)
5. Aquaporin3 (Aqp3) Expression in Oral Epithelium in Oral Lichen Planus, Experimental and Molecular Pathology (2020)
6. Serum and Saliva Collagenase-3 (Mmp-13) in Patients With Oral Lichen Planus and Oral Squamous Cell Carcinoma, Medical Journal of the Islamic Republic of Iran (2015)
7. Association of Oral Lichen Planus and Its Treatment on Tumor Necrosis Factor-Alpha: A Review Literature and Meta-Analysis, Middle East Journal of Rehabilitation and Health Studies (2021)
8. A Systematic Review of Interleukin-17 in Oral Lichen Planus: From Etiopathogenesis to Treatment, Clinical Medicine and Research (2023)
Experts (# of related papers)
View all Related Experts
Mahdieh-Sadat Moosavi (10)
Nafiseh Sheykhbahaei (3)
Other Related Docs
9. Patch Test of Dental Materials in Oral Lichen Planus With Considering the Role of Saliva, Scientific Reports (2021)
10. Muscarinic Cholinergic Receptors in Minor Salivary Gland Tissues of Patients With Oral Lichen Planus: A Case-Control Study, Journal of Oral Pathology and Medicine (2020)
11. Mucin 5B in Saliva and Serum of Patients With Oral Lichen Planus, Scientific Reports (2017)
12. “Exploring the Link Between Oral Lichen Planus and Xerostomia: A Systematic Literature Review”, Immunity, Inflammation and Disease (2024)
13. Evaluation of the Effects of Dental Implants on Oral Lesions, Journal of Contemporary Dental Practice (2015)
14. Salivary Gland Performance in Autoimmune Diseases: Review and Meta-Analysis, Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine (2020)
15. Saliva 8-Hydroxy-2'-Deoxyguanosine Changes Following Radiotherapy in Patients With Head and Neck Cancer, Dental Cadmos (2016)
16. The Potential Roles of Th17 Cells in the Pathogenesis of Oral Lichen Planus, Inflammation Research (2023)
17. Interleukin-10 in Oral Lichen Planus – Review and Meta-Analysis, Current Immunology Reviews (2020)
18. Management of Oral Lichen Planus by 980 Nm Diode Laser, Journal of Lasers in Medical Sciences (2017)
19. Comparison of Oral Lichen Planus and Systemic Lupus Erythematosus in Interleukins Level, Archives of Iranian Medicine (2015)
20. Salivary Oxidative Stress in Oral Lichen Planus Treated With Triamcinolone Mouthrinse, Dental Research Journal (2017)
21. Serum and Salivary Levels of Lactate Dehydrogenase in Oral Squamous Cell Carcinoma, Oral Lichen Planus and Oral Lichenoid Reaction, BMC Oral Health (2020)