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Protective Effects of Tropisetron on Cerulein-Induced Acute Pancreatitis in Mice Publisher Pubmed



Rahimian R1, 2 ; Zirak MR3 ; Seyedabadi M4 ; Keshavarz M4, 5 ; Rashidian A2 ; Kazmi S6 ; Jafarian AH7 ; Karimi G8 ; Mousavizadeh K9
Authors
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Authors Affiliations
  1. 1. Department of Psychiatry and Neuroscience, Faculty of Medicine, Universite Laval, Quebec City, Quebec, Canada
  2. 2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  5. 5. Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Cancer Molecular Pathology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Cellular and Molecular Research Center and Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2017


Abstract

Acute pancreatitis (AP) causes morbidity and mortality. The aim of the present study was to investigate the protective effect of tropisetron against AP induced by cerulein. Cerulein (50 μg/kg, 5 doses) was used to induce AP in mice. Six hours after final cerulein injection, animals were decapitated. Hepatic/pancreatic enzymes in the serum, pancreatic content of malondialdehyde (MDA), pro-inflammatory cytokines and myeloperoxidase (MPO) activity were measured. Tropisetron significantly attenuated pancreatic injury markers and decreased the amount of elevated serum amylase, lipase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), MPO activities and pro-inflammatory cytokines levels caused by AP in mice. Tropisetron didn't affect the pancreatic levels of MDA. Our results suggest that tropisetron could attenuate cerulein-induced AP by combating inflammatory signaling. Further clinical studies are needed to confirm its efficacy in patients with AP. © 2017 Elsevier Masson SAS
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