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Combination of Resistance and Aerobic Exercise for Six Months Improves Bone Mass and Physical Function in Hiv Infected Individuals: A Randomized Controlled Trial Publisher Pubmed



Ghayomzadeh M1, 2 ; Earnest CP3 ; Hackett D1 ; Seyedalinaghi S2 ; Navalta JW4 ; Gholami M5 ; Hosseini Rouzbahani N6 ; Mohraz M2 ; Voltarelli FA7
Authors
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Authors Affiliations
  1. 1. Physical Activity, Lifestyle, Ageing and Wellbeing Faculty Research Group, School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Lidcombe, NSW, Australia
  2. 2. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Health and Kinesiology, Texas A&M University College Station, College Station, TX, United States
  4. 4. Department of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, NV, United States
  5. 5. Department of Medical Microbiology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Immunology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
  7. 7. Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiab'a, Brazil

Source: Scandinavian Journal of Medicine and Science in Sports Published:2021


Abstract

To evaluate the effect of combined resistance and aerobic training (RT+AT) on regional bone mineral density (BMD) and physical performance in people living with HIV (PLWH). Forty PLWH (20 men and 20 women) were randomized into RT+AT group (n = 20; age = 38.3 ± 4.9) or non-exercise control group (n = 20; age = 37.9 ± 5.1). The RT+AT group was required to perform a nonlinear periodized resistance training program targeting large muscle groups followed by 20 min aerobic exercise at 65-80% of maximal heart rate. Participants in RT+AT performed three supervised sessions per week for 6-months, whereas participants in the control group were instructed to continue with their current lifestyle habits. The primary outcome was bone mineral density (lumbar spine (L2-L4), femoral neck, and distal 1/3 radius). Secondary outcomes included physical function, anthropometry, inflammatory markers, and growth factors. The RT+AT group demonstrated a significant increase in BMD at follow-up for the Lumbar spine (L2-L4), femoral neck, and 1/3 radius (all, P <.05), and There were no gender differences in the training response between men and women for any of the BMD regions. Similar findings were also observed for lean body mass, IGF1and Adiponectin (P <.001). We observed a decrease in percent body fat, fat mass, IL-6, TNF-α, and myostatin in the RT+AT group (P <.001). Finally, there was a significant increase in handgrip strength and gait speed for both women and men in the RT+AT group (P <.001). A combination of resistance and aerobic training appears to be a feasible and effective means for counteracting bone loss and improving various inflammatory markers, physical function, and growth hormones in PLWH. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
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