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Prevalence and Severity of Depression in Chronic Viral Hepatitis in Iran Publisher



Hazaveh MM1 ; Toosi TD1, 2 ; Toosi MN2 ; Tavakoli A1 ; Shahbazi F3
Authors
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Authors Affiliations
  1. 1. Rheumatology Research Centre, Vali-asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Gastrointestinal Research Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, P.O. Box 1419733141, Tehran, Iran
  3. 3. Department of Biology, Payame Noor University, Iran

Source: Gastroenterology Report Published:2015


Abstract

Aim: The aim of this study was to compare the prevalence and severity of depression in chronic hepatitis B (CHB) patients, chronic hepatitis C (CHC) patients, and healthy participants. Methods: Two hundred and fifty-three persons participated in this cross-sectional study between 2011 and 2012 in Imam Khomeini Hospital. The prevalence and severity of depression were assessed using the Hamilton Scale. Results: There was significantly higher prevalence of depression in CHC patients (35.9%) than in healthy participants (11.3%) and CHB patients (19.8%) (both P < 0.01). However, CHB and CHC patients did not differ significantly in their depression prevalence after excluding inactive hepatitis B surface antigen (HBsAg) carriers (29.3% vs. 35.9%; P > 0.05). Inactive HBsAg carriers differed significantly from CHB patients—excluding inactive HBsAg carriers—in depression prevalence (10.0% vs. 29.3%; P < 0.05). No statistically significant difference was found in depression severity between all groups (P > 0.05). Conclusion: Depression screening in chronic hepatitis B and chronic hepatitis C patients may be beneficial in disease management. � VC The Author(s) 2015.