Comparing Efficacy of Enteral Nutrition Plus Ranitidine and Enteral Nutrition Alone As Stress Ulcer Prophylaxis

Comparing Efficacy of Enteral Nutrition Plus Ranitidine and Enteral Nutrition Alone As Stress Ulcer Prophylaxis Publisher Pubmed

Nourian A¹ ; Mohammadi M² ; Beigmohammadi MT² ; Taher M³ ; Dadvar Z³ ; Malekolkottab M¹ ; Ramezani M² ; Khalili H¹

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1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Imam Khomeini Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Internal Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Comparative Effectiveness Research Published:2018

Abstract

Aim: Adequacy of enteral nutrition (EN) alone as stress ulcer prophylaxis (SUP) is controversial. The aim of this study was to compare efficacy of EN alone and ranitidine plus EN as SUP. Method: Critically ill adults with indications to receive SUP were randomized to ranitidine 50 mg IV every 8 h plus EN (SUP) or EN alone (non-SUP) group for 7 days. Besides, endoscopy was performed at the time of recruitment and on day 7. Results: During the study period, only one patient in each group of SUP and non-SUP experienced gastrointestinal bleeding. At the time of recruitment, gastric erosion and erythema were the most endoscopic findings in the SUP and non-SUP groups. These findings did not significantly change at the end of the study (p = 0.21). Conclusion: EN was at least effective as ranitidine plus EN as SUP. © 2018 Future Medicine Ltd.

Experts (# of related papers)

Mohammad Hassan Javanbakht (1)

Style	Citing Format
MLA	Nourian A, et al.. "Comparing Efficacy of Enteral Nutrition Plus Ranitidine and Enteral Nutrition Alone As Stress Ulcer Prophylaxis." Journal of Comparative Effectiveness Research, vol. 7, no. 5, 2018, pp. 493-501.
APA	Nourian A, Mohammadi M, Beigmohammadi MT, Taher M, Dadvar Z, Malekolkottab M, Ramezani M, Khalili H (2018). Comparing Efficacy of Enteral Nutrition Plus Ranitidine and Enteral Nutrition Alone As Stress Ulcer Prophylaxis. Journal of Comparative Effectiveness Research, 7(5), 493-501.
Chicago	Nourian A, Mohammadi M, Beigmohammadi MT, Taher M, Dadvar Z, Malekolkottab M, Ramezani M, Khalili H. "Comparing Efficacy of Enteral Nutrition Plus Ranitidine and Enteral Nutrition Alone As Stress Ulcer Prophylaxis." Journal of Comparative Effectiveness Research 7, no. 5 (2018): 493-501.
Harvard	Nourian A et al. (2018) 'Comparing Efficacy of Enteral Nutrition Plus Ranitidine and Enteral Nutrition Alone As Stress Ulcer Prophylaxis', Journal of Comparative Effectiveness Research, 7(5), pp. 493-501.
Vancouver	Nourian A, Mohammadi M, Beigmohammadi MT, Taher M, Dadvar Z, Malekolkottab M, et al.. Comparing Efficacy of Enteral Nutrition Plus Ranitidine and Enteral Nutrition Alone As Stress Ulcer Prophylaxis. Journal of Comparative Effectiveness Research. 2018;7(5):493-501.
BibTex	@article{ author = {Nourian A and Mohammadi M and Beigmohammadi MT and Taher M and Dadvar Z and Malekolkottab M and Ramezani M and Khalili H}, title = {Comparing Efficacy of Enteral Nutrition Plus Ranitidine and Enteral Nutrition Alone As Stress Ulcer Prophylaxis}, journal = {Journal of Comparative Effectiveness Research}, volume = {7}, number = {5}, pages = {493-501}, year = {2018} }
RIS	TY - JOUR AU - Nourian A AU - Mohammadi M AU - Beigmohammadi MT AU - Taher M AU - Dadvar Z AU - Malekolkottab M AU - Ramezani M AU - Khalili H TI - Comparing Efficacy of Enteral Nutrition Plus Ranitidine and Enteral Nutrition Alone As Stress Ulcer Prophylaxis JO - Journal of Comparative Effectiveness Research VL - 7 IS - 5 SP - 493 EP - 501 PY - 2018 ER -

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