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Preoperative Monocyte Count As a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases Publisher Pubmed



Gilani MM1 ; Kazemi Z2 ; Zamani N1 ; Shahrami H2 ; Ghahghaeinezamabadi A1 ; Sheikham S1
Authors
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Authors Affiliations
  1. 1. Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Asian Pacific Journal of Cancer Prevention Published:2018


Abstract

Background: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. Methods: We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence. Results: The majority of patients had tumors with the following characteristics: endometrioid histology (83.1%), low grade (grade I-II, 71.7%) and stage I disease (68.1%). The mean ± SD monocyte, neutrophil and platelet counts were 8.23 x 109/L ± 3.56 x 109/L, 64.0 x 109/L ± 11.3 x 109/L and 261.6 x 109/L ± 74.6 x 109. Statistically significant associations were noted with between preoperative monocyte count and tumor stage (p value=0.044), recurrence (p value < 0.001) and omentum involvement (p value < 0.001) but not with tumor grade (p value=0.897), depth of myometrium involvement (p value=0.479), lymphovascular space invasion (p value=0.269) and lymph node involvement (p value=0.377). Conclusion: An elevated preoperative monocyte count is related to more aggressive tumors and a higher recurrence rate in patients with endometrial cancer. © 2017, Asian Pacific Organization for Cancer Prevention.