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Five-Year Changes of Anterior Corneal Indices in Diabetics Versus Non-Diabetics: The Shahroud Eye Cohort Study Publisher Pubmed



Hashemi H1 ; Asgari S2 ; Mehravaran S3 ; Emamian MH4 ; Fotouhi A5
Authors
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Authors Affiliations
  1. 1. Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran
  2. 2. Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
  3. 3. Stein Eye Institute, University of California, Los Angeles, CA, United States
  4. 4. Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran
  5. 5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Eye Research Published:2019


Abstract

Purpose: To compare 5-year changes of central and peripheral corneal thickness, corneal volume, and keratometry between diabetic and non-diabetic individuals (>40 years) in a population-based study. Materials and Methods: Right eye corneal indices of the 333 diabetic persons were compared with 2865 non-diabetics. Studied indices included the apical corneal thickness (ACT), minimal corneal thickness (MCT), thickness values on corneal rings of 4 mm, 6 mm, and 8 mm in diameter, the volume of the 10 mm of the corneal diameter, and the central 3 mm keratometry in two steep (Kmax) and flat (Kmin) axes as measured with Pentacam (Oculus, Inc, Lynnwood, WA). Results: In the diabetic and non-diabetic groups, respectively, the 5-year change was +0.1 ± 11.9 and −1.2 ± 11.9 μm (p = 0.035) for ACT, −1.1 ± 12.1 and −2.4 ± 11.9 μm (p = 0.056) for MCT, −3.9 ± 12.6 and −5.1 ± 12.3 μm (p = 0.007) for the 4 mm ring, −5.0 ± 15.3 and −7.5 ± 14.5 μm (p = 0.006) for the 6 mm ring, and −7.0 ± 20.1 and −10.8 ± 19.2 μm (p = 0.011) for the 8 mm ring. The diabetic group showed less reduction in corneal volume (−0.5 ± 1.8 mm 3 ) compared to non-diabetics (−0.8 ± 1.6 mm 3 ) (p = 0.030). Kmax (+0.3 ± 0.5D vs. +0.4 ± 0.5, p = 0.028) and Kmin (+0.4 ± 0.5D vs. +0.5 ± 0.5, p = 0.005) showed less change in diabetics compared to non-diabetics. Conclusions: The overall patterns of change in corneal thickness and shape in over 40-year old diabetics are similar to non-diabetics, such that with aging, reduced thickness and increased keratometry take the cornea towards a prolate shape. However, the age-related changes in central and peripheral corneal thickness, volume and corneal shape are less pronounced in diabetic subjects. © 2018, © 2018 Taylor & Francis Group, LLC.