Altered D2 Receptor and Transcription Factor Eb Expression in Offspring of Aggressive Male Rats, Along With Having Depressive and Anxiety-Like Behaviors

Altered D2 Receptor and Transcription Factor Eb Expression in Offspring of Aggressive Male Rats, Along With Having Depressive and Anxiety-Like Behaviors Publisher Pubmed

Khalifeh S¹ ; Khodagholi F² ; Zarrindast MR^{3, 4} ; Alizadeh R⁵ ; Asadi S⁶ ; Mohammadi Kamsorkh H⁶ ; Nasehi M¹ ; Ghadami A¹ ; Sadatshirazi MS³

Show Affiliations

1. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
6. Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Neuroscience Published:2021

Abstract

Aim of the study: Dopaminergic system in the amygdala and Prefrontal Cortex (PFC) influences fear and anxiety through Dopaminergic Receptors (DR), especially DR-D1 and DR-D2. Transcription Factor EB (TFEB) is an upstream protein of the autophagy-lysosome pathway. Materials and methods: In this study we have evaluated the behavioral mood variations, and expression of DR-D2 and TFEB genes in the amygdala and PFC of aggressive male rats’ offspring. Results: Anxiety and depression-like behaviors were observed, but intra-ventricle injection of DR-D2 antagonist (Sulpiride) has shown to be efficient in reducing negative behavioral changes in offspring. Furthermore, DR-D2 gene expression was increased in the amygdala and PFC of aggressive male rats’ offspring, which the injection of Sulpiride decreased it significantly. TFEB gene expression was also decreased in the amygdala and PFC of aggressive male rats’ offspring, but the blockade of DR-D2 had no effect on it. Conclusions: The current data suggests the possible influence of dopaminergic receptors D2 and TFEB genes on the behavioral changes which is modified by having an aggressive father. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

2. Paternal Aggression in Early-Life Impairs the Spatial Memory and Passive Avoidance Learning in Adulthood of Male Rats: The Possible Role of Drd2, Basic and Clinical Neuroscience (2023)

3. The Potential of Targeting Autophagy-Related Non-Coding Rnas in the Treatment of Alzheimer’S and Parkinson’S Diseases, Cellular and Molecular Neurobiology (2024)

4. Modulation of the Effects of the Cannabinoid Agonist, Acpa, on Spatial and Non-Spatial Novelty Detection in Mice by Dopamine D1 Receptor Drugs Infused Into the Basolateral Amygdala, Behavioural Brain Research (2015)

Experts (# of related papers)

Hamid Reza Mirzaei (1)

Fatemeh Nabavizadeh Rafsanjani (1)

Style	Citing Format
MLA	Khalifeh S, et al.. "Altered D2 Receptor and Transcription Factor Eb Expression in Offspring of Aggressive Male Rats, Along With Having Depressive and Anxiety-Like Behaviors." International Journal of Neuroscience, vol. 131, no. 8, 2021, pp. 789-799.
APA	Khalifeh S, Khodagholi F, Zarrindast MR, Alizadeh R, Asadi S, Mohammadi Kamsorkh H, Nasehi M, Ghadami A, Sadatshirazi MS (2021). Altered D2 Receptor and Transcription Factor Eb Expression in Offspring of Aggressive Male Rats, Along With Having Depressive and Anxiety-Like Behaviors. International Journal of Neuroscience, 131(8), 789-799.
Chicago	Khalifeh S, Khodagholi F, Zarrindast MR, Alizadeh R, Asadi S, Mohammadi Kamsorkh H, Nasehi M, Ghadami A, Sadatshirazi MS. "Altered D2 Receptor and Transcription Factor Eb Expression in Offspring of Aggressive Male Rats, Along With Having Depressive and Anxiety-Like Behaviors." International Journal of Neuroscience 131, no. 8 (2021): 789-799.
Harvard	Khalifeh S et al. (2021) 'Altered D2 Receptor and Transcription Factor Eb Expression in Offspring of Aggressive Male Rats, Along With Having Depressive and Anxiety-Like Behaviors', International Journal of Neuroscience, 131(8), pp. 789-799.
Vancouver	Khalifeh S, Khodagholi F, Zarrindast MR, Alizadeh R, Asadi S, Mohammadi Kamsorkh H, et al.. Altered D2 Receptor and Transcription Factor Eb Expression in Offspring of Aggressive Male Rats, Along With Having Depressive and Anxiety-Like Behaviors. International Journal of Neuroscience. 2021;131(8):789-799.
BibTex	@article{ author = {Khalifeh S and Khodagholi F and Zarrindast MR and Alizadeh R and Asadi S and Mohammadi Kamsorkh H and Nasehi M and Ghadami A and Sadatshirazi MS}, title = {Altered D2 Receptor and Transcription Factor Eb Expression in Offspring of Aggressive Male Rats, Along With Having Depressive and Anxiety-Like Behaviors}, journal = {International Journal of Neuroscience}, volume = {131}, number = {8}, pages = {789-799}, year = {2021} }
RIS	TY - JOUR AU - Khalifeh S AU - Khodagholi F AU - Zarrindast MR AU - Alizadeh R AU - Asadi S AU - Mohammadi Kamsorkh H AU - Nasehi M AU - Ghadami A AU - Sadatshirazi MS TI - Altered D2 Receptor and Transcription Factor Eb Expression in Offspring of Aggressive Male Rats, Along With Having Depressive and Anxiety-Like Behaviors JO - International Journal of Neuroscience VL - 131 IS - 8 SP - 789 EP - 799 PY - 2021 ER -

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