A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation

A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation Publisher Pubmed

Saadatzade A^{1, 2} ; Shabaninezhad K³ ; Handali S⁴ ; Moghimipour E^{1, 5}

Show Affiliations

1. Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Department of Food and Drug Control, Faculty of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran
3. Department of Pharmaceutics, Faculty of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran
4. Medical Biomaterials Research Centre (MBRC), Tehran University of Medical Sciences, Tehran, Iran
5. Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Microbial Pathogenesis Published:2024

Abstract

Probiotic strains offer a novel and potentially effective approach to treat oral candidiasis. Buccal mucoadhesive films have attracted considerable attention in recent years due to their unique ability to adhere and persist on the oral mucosa, while gradually releasing their encapsulated drug content. Therefore, the aim of the study was to develop mucoadhesive films containing probiotic extract for treatment of oral candidiasis. Mucoadhesive films were fabricated with hydrophilic polymers, such as polyvinyl alcohol (PVA) and hydroxy propyl methyl cellulose (HPMC). Then, films were evaluated regarding their thickness, pH, tensile strength and elongation, swelling, in vitro release and antifungal activity. The type of polymer used had an impact on the mechanical properties, swelling and release of the films. Films prepared using PVA showed significantly higher tensile strength and elongation at break values compared to those prepared using HPMC. However, swelling index increased with enhancing HPMC concentration in the films. The release of probiotic extract from the film prepared with HPMC occurred slowly. Based on these results, films containing 54 % HPMC and 26 % PVA were selected as optimal formulation. Moreover, it was found that optimal film containing probiotic extract could inhibit the growth of Candida albicans. Regarding to the obtained results, probiotic oral adhesive mucoadhesive films can be considered as a promising alternative to traditional methods in the treatment of candidiasis. © 2024 Elsevier Ltd

Style	Citing Format
MLA	Saadatzade A, et al.. "A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation." Microbial Pathogenesis, vol. 196, no. , 2024, pp. -.
APA	Saadatzade A, Shabaninezhad K, Handali S, Moghimipour E (2024). A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation. Microbial Pathogenesis, 196(), -.
Chicago	Saadatzade A, Shabaninezhad K, Handali S, Moghimipour E. "A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation." Microbial Pathogenesis 196, no. (2024): -.
Harvard	Saadatzade A et al. (2024) 'A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation', Microbial Pathogenesis, 196(), pp. -.
Vancouver	Saadatzade A, Shabaninezhad K, Handali S, Moghimipour E. A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation. Microbial Pathogenesis. 2024;196():-.
BibTex	@article{ author = {Saadatzade A and Shabaninezhad K and Handali S and Moghimipour E}, title = {A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation}, journal = {Microbial Pathogenesis}, volume = {196}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Saadatzade A AU - Shabaninezhad K AU - Handali S AU - Moghimipour E TI - A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation JO - Microbial Pathogenesis VL - 196 IS - SP - EP - PY - 2024 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract