Is Fev1 Associated With Quality of Life in Children With Cystic Fibrosis? an Original Article

Is Fev1 Associated With Quality of Life in Children With Cystic Fibrosis? an Original Article Publisher

Shirzadi R¹ ; Navaei S¹ ; Modaresi M¹ ; Masiha F²

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1. Pediatric Respiratory and Sleep Medicine Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2. Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Source: Immunopathologia Persa Published:2020

Abstract

Introduction: Cystic fibrosis (CF) is a serious genetic life-shortening disease. Quality of life (QoL) measurement related to CF children is a relatively new field of research, which includes the patient's perspective in research and clinical practice. Objectives: This study aimed to evaluate the QoL in children with CF and its association with FEV1 (forced expiratory volume in 1 second). Patients and Methods: This cross-sectional study was carried out on 7-14 years old children with CF attending children's medical center from March 2017 to March 2018. Throat swab cultures and spirometry evaluation was performed for all patients. FEV1 was determined and the 6-min walk test (6MWT) was conducted. The patient's psychological status was assessed using the Persian version of pediatric QoL inventory. ANOVA, t test, and chi-square tests were used for data analysis. Results: Seventy-six subjects with the mean age of 10.49±3.18 years were studied since 59% of them (n=44) were boys. The mean total QoL was 65.34±17.73. Patients with lower pulmonary function had a lower QoL. There was a significant association between FEV1 and school and emotional functioning (P= 0.005 and P= 0.002, respectively). A significant association was found between SPO2 (peripheral capillary oxygen saturation) reduction after 6MWT and FEV1 decline (P= 0.001). Additionally, a significant association was detected between FEV1 and the distance walked during 6MWT (P= 0.030). Conclusion: Regarding the association between pulmonary function and QoL in CF patients and lower QoL score in our study, the importance of assessing pulmonary function in these patients should not be neglected. Copyright © 2020 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Style	Citing Format
MLA	Shirzadi R, et al.. "Is Fev1 Associated With Quality of Life in Children With Cystic Fibrosis? an Original Article." Immunopathologia Persa, vol. 6, no. 1, 2020, pp. -.
APA	Shirzadi R, Navaei S, Modaresi M, Masiha F (2020). Is Fev1 Associated With Quality of Life in Children With Cystic Fibrosis? an Original Article. Immunopathologia Persa, 6(1), -.
Chicago	Shirzadi R, Navaei S, Modaresi M, Masiha F. "Is Fev1 Associated With Quality of Life in Children With Cystic Fibrosis? an Original Article." Immunopathologia Persa 6, no. 1 (2020): -.
Harvard	Shirzadi R et al. (2020) 'Is Fev1 Associated With Quality of Life in Children With Cystic Fibrosis? an Original Article', Immunopathologia Persa, 6(1), pp. -.
Vancouver	Shirzadi R, Navaei S, Modaresi M, Masiha F. Is Fev1 Associated With Quality of Life in Children With Cystic Fibrosis? an Original Article. Immunopathologia Persa. 2020;6(1):-.
BibTex	@article{ author = {Shirzadi R and Navaei S and Modaresi M and Masiha F}, title = {Is Fev1 Associated With Quality of Life in Children With Cystic Fibrosis? an Original Article}, journal = {Immunopathologia Persa}, volume = {6}, number = {1}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Shirzadi R AU - Navaei S AU - Modaresi M AU - Masiha F TI - Is Fev1 Associated With Quality of Life in Children With Cystic Fibrosis? an Original Article JO - Immunopathologia Persa VL - 6 IS - 1 SP - EP - PY - 2020 ER -

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