Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation

Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation Publisher Pubmed

Cui J ; Chen Z ; Cheng Y H ; Nie J ; Zhu M H ; Xiang C ; Chauvin S ; Lassoued W ; Liu C ; Padhan K ; Song J ; Pai J A ; Ocon B ; Yang Y Show All Authors

Cui J
Chen Z
Cheng Y H
Nie J
Zhu M H
Xiang C
Chauvin S
Lassoued W
Liu C
Padhan K
Song J
Pai J A
Ocon B
Yang Y
Yao Y
Park A Y
Gabrielski J Q
Zheng L
Jiang P D
Zhang Y
Jing H
Xu L
Chen V
Calabresi B A
Pittaluga S
Kleiner D E
Dalgard C L
Sari S
Can S
Karakoc Aydiner E
Baris S
Erman B
Field M
Silvester J A
Saccocia G
Buhamrah E K
Husain K
Chavoshzadeh Z
Rezaei N
Islek A
Bas H
Devrez F D
Mackeh R
Fuss I J
Reich D S
Bailey S
Sater H A
Gulley J L
Kabat J
Smelkinson M
Ganesan S
Grayson P C
Redekar N
Lack J
Lu Z
Lo B
Abolhassani H
Ozen A
Bousvaros A
Snapper S B
Butcher E C
Ravell J
Bosselut R
Su H C
Wu C
Lenardo M J

Source: Nature Published:2026

Abstract

Inflammatory bowel disease (IBD) causes chronic suffering from gastrointestinal inflammation and dysfunction that can progress to colon cancer1,2. The prevalence of the disease is increasing, and there is an urgent need to better understand its pathogenic mechanisms to improve treatment. We show that GPR15—a G-protein-coupled receptor expressed in immune cells and described previously as an entry co-factor for human and simian immunodeficiency viruses3—is a marker and homing receptor for a subset of intramucosal GPR15-guided regulatory CD8+ T lymphocytes (CD8+ TIGR cells). Deleterious GPR15 gene variants in humans cause defective homing of CD8+ TIGR cells and are associated with severe early-onset IBD. Moreover, CD8+ TIGR cells are reduced in the intestinal mucosa of individuals with sporadic IBD. In mice, GPR15 deficiency impairs colonic homing of CD8+ TIGR cells, leading to accumulation of inflammatory macrophages and increased susceptibility to colitis. CD8+ TIGR cells potently kill macrophages activated by intestinal damage or disease using Fas ligand and TNF-related weak inducer of apoptosis (TWEAK). The identification of CD8+ TIGR cells yields new insights into organ-specific immune regulation and potential therapeutics for IBD. © The Author(s) 2026.

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Style	Citing Format
MLA	Cui J, et al.. "Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation." Nature, vol. 656, no. 8129, 2026, pp. 1003-1012.
APA	Cui J, Chen Z, Cheng Y H, Nie J, Zhu M H, Xiang C, Chauvin S, Lassoued W, Liu C, Padhan K, Song J, Pai J A, Ocon B, Yang Y, Yao Y, Park A Y, Gabrielski J Q, Zheng L, Jiang P D, ... Lenardo M J (2026). Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation. Nature, 656(8129), 1003-1012.
Chicago	Cui J, Chen Z, Cheng Y H, Nie J, Zhu M H, Xiang C, Chauvin S, et al.. "Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation." Nature 656, no. 8129 (2026): 1003-1012.
Harvard	Cui J et al. (2026) 'Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation', Nature, 656(8129), pp. 1003-1012.
Vancouver	Cui J, Chen Z, Cheng Y H, Nie J, Zhu M H, Xiang C, et al.. Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation. Nature. 2026;656(8129):1003-1012.
BibTex	@article{ author = {Cui J and Chen Z and Cheng Y H and Nie J and Zhu M H and Xiang C and Chauvin S and Lassoued W and Liu C and Padhan K and Song J and Pai J A and Ocon B and Yang Y and Yao Y and Park A Y and Gabrielski J Q and Zheng L and Jiang P D and Zhang Y and Jing H and Xu L and Chen V and Calabresi B A and Pittaluga S and Kleiner D E and Dalgard C L and Sari S and Can S and Karakoc Aydiner E and Baris S and Erman B and Field M and Silvester J A and Saccocia G and Buhamrah E K and Husain K and Chavoshzadeh Z and Rezaei N and Islek A and Bas H and Devrez F D and Mackeh R and Fuss I J and Reich D S and Bailey S and Sater H A and Gulley J L and Kabat J and Smelkinson M and Ganesan S and Grayson P C and Redekar N and Lack J and Lu Z and Lo B and Abolhassani H and Ozen A and Bousvaros A and Snapper S B and Butcher E C and Ravell J and Bosselut R and Su H C and Wu C and Lenardo M J}, title = {Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation}, journal = {Nature}, volume = {656}, number = {8129}, pages = {1003-1012}, year = {2026} }
RIS	TY - JOUR AU - Cui J AU - Chen Z AU - Cheng Y H AU - Nie J AU - Zhu M H AU - Xiang C AU - Chauvin S AU - Lassoued W AU - Liu C AU - Padhan K AU - Song J AU - Pai J A AU - Ocon B AU - Yang Y AU - Yao Y AU - Park A Y AU - Gabrielski J Q AU - Zheng L AU - Jiang P D AU - Zhang Y AU - Jing H AU - Xu L AU - Chen V AU - Calabresi B A AU - Pittaluga S AU - Kleiner D E AU - Dalgard C L AU - Sari S AU - Can S AU - Karakoc Aydiner E AU - Baris S AU - Erman B AU - Field M AU - Silvester J A AU - Saccocia G AU - Buhamrah E K AU - Husain K AU - Chavoshzadeh Z AU - Rezaei N AU - Islek A AU - Bas H AU - Devrez F D AU - Mackeh R AU - Fuss I J AU - Reich D S AU - Bailey S AU - Sater H A AU - Gulley J L AU - Kabat J AU - Smelkinson M AU - Ganesan S AU - Grayson P C AU - Redekar N AU - Lack J AU - Lu Z AU - Lo B AU - Abolhassani H AU - Ozen A AU - Bousvaros A AU - Snapper S B AU - Butcher E C AU - Ravell J AU - Bosselut R AU - Su H C AU - Wu C AU - Lenardo M J TI - Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation JO - Nature VL - 656 IS - 8129 SP - 1003 EP - 1012 PY - 2026 ER -

Style

Citing Format

MLA

Cui J, et al.. "Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation." Nature, vol. 656, no. 8129, 2026, pp. 1003-1012.

APA

Cui J, Chen Z, Cheng Y H, Nie J, Zhu M H, Xiang C, Chauvin S, Lassoued W, Liu C, Padhan K, Song J, Pai J A, Ocon B, Yang Y, Yao Y, Park A Y, Gabrielski J Q, Zheng L, Jiang P D, ... Lenardo M J (2026). Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation. Nature, 656(8129), 1003-1012.

Chicago

Cui J, Chen Z, Cheng Y H, Nie J, Zhu M H, Xiang C, Chauvin S, et al.. "Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation." Nature 656, no. 8129 (2026): 1003-1012.

Harvard

Cui J et al. (2026) 'Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation', Nature, 656(8129), pp. 1003-1012.

Vancouver

Cui J, Chen Z, Cheng Y H, Nie J, Zhu M H, Xiang C, et al.. Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation. Nature. 2026;656(8129):1003-1012.

BibTex

@article{ author = {Cui J and Chen Z and Cheng Y H and Nie J and Zhu M H and Xiang C and Chauvin S and Lassoued W and Liu C and Padhan K and Song J and Pai J A and Ocon B and Yang Y and Yao Y and Park A Y and Gabrielski J Q and Zheng L and Jiang P D and Zhang Y and Jing H and Xu L and Chen V and Calabresi B A and Pittaluga S and Kleiner D E and Dalgard C L and Sari S and Can S and Karakoc Aydiner E and Baris S and Erman B and Field M and Silvester J A and Saccocia G and Buhamrah E K and Husain K and Chavoshzadeh Z and Rezaei N and Islek A and Bas H and Devrez F D and Mackeh R and Fuss I J and Reich D S and Bailey S and Sater H A and Gulley J L and Kabat J and Smelkinson M and Ganesan S and Grayson P C and Redekar N and Lack J and Lu Z and Lo B and Abolhassani H and Ozen A and Bousvaros A and Snapper S B and Butcher E C and Ravell J and Bosselut R and Su H C and Wu C and Lenardo M J}, title = {Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation}, journal = {Nature}, volume = {656}, number = {8129}, pages = {1003-1012}, year = {2026} }

RIS

TY - JOUR
AU - Cui J
AU - Chen Z
AU - Cheng Y H
AU - Nie J
AU - Zhu M H
AU - Xiang C
AU - Chauvin S
AU - Lassoued W
AU - Liu C
AU - Padhan K
AU - Song J
AU - Pai J A
AU - Ocon B
AU - Yang Y
AU - Yao Y
AU - Park A Y
AU - Gabrielski J Q
AU - Zheng L
AU - Jiang P D
AU - Zhang Y
AU - Jing H
AU - Xu L
AU - Chen V
AU - Calabresi B A
AU - Pittaluga S
AU - Kleiner D E
AU - Dalgard C L
AU - Sari S
AU - Can S
AU - Karakoc Aydiner E
AU - Baris S
AU - Erman B
AU - Field M
AU - Silvester J A
AU - Saccocia G
AU - Buhamrah E K
AU - Husain K
AU - Chavoshzadeh Z
AU - Rezaei N
AU - Islek A
AU - Bas H
AU - Devrez F D
AU - Mackeh R
AU - Fuss I J
AU - Reich D S
AU - Bailey S
AU - Sater H A
AU - Gulley J L
AU - Kabat J
AU - Smelkinson M
AU - Ganesan S
AU - Grayson P C
AU - Redekar N
AU - Lack J
AU - Lu Z
AU - Lo B
AU - Abolhassani H
AU - Ozen A
AU - Bousvaros A
AU - Snapper S B
AU - Butcher E C
AU - Ravell J
AU - Bosselut R
AU - Su H C
AU - Wu C
AU - Lenardo M J
TI - Gpr15-Guided Cd8+ T Regulatory Cells Control Intestinal Inflammation
JO - Nature
VL - 656
IS - 8129
SP - 1003
EP - 1012
PY - 2026
ER -

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Abstract