Association Between Previous Spontaneous Abortion and Pre-Eclampsia During a Subsequent Pregnancy Publisher Pubmed



Sepidarkish M¹ ; Almasihashiani A¹ ; Maroufizadeh S¹ ; Vesali S¹ ; Pirjani R² ; Samani RO²
Source: International Journal of Gynecology and Obstetrics Published:2016

Abstract

Objective: To determine the impact of a history of spontaneous abortion on pre-eclampsia during a subsequent pregnancy. Methods: A cross-sectional study enrolled pregnant women admitted to obstetrics and gynecology wards at 103 hospitals in Tehran, Iran for delivery between July 6 and July 21, 2015. Consenting participants were interviewed by midwives; data were collected using a five-part questionnaire and patients’ medical records were retrieved. Patient data were analyzed by multiple logistic regression to identify variables associated with increased odds of pre-eclampsia. Results: In total, 5170 patients were interviewed and 252 had experienced pre-eclampsia. The number of previous spontaneous abortions was found to be associated with pre-eclampsia, and a higher number of previous spontaneous abortions was associated with increased odds of patients having experienced pre-eclampsia (adjusted odds ratio 1.28, 95% confidence interval 1.03–1.59; P=0.025). Conclusion: A history of spontaneous abortion was associated with increased odds of pre-eclampsia during a subsequent pregnancy. © 2016 International Federation of Gynecology and Obstetrics.