Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes

Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes Publisher

Fathi M¹ ; Nikzamir AR^{2, 3} ; Esteghamati A³ ; Nakhjavani M³ ; Yekaninejad MS⁴

Show Affiliations

1. Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, IR, Iran
2. Department of Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, IR, Iran
3. Endocrinology and Metabolism Research Center (EMRC), Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, IR, Iran
4. Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, IR, Iran

Source: Iranian Red Crescent Medical Journal Published:2015

Abstract

Background: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and vascular endothelial growth factor (VEGF) polymorphisms have been shown to associate with diabetic nephropathy (DN). Objectives: We examined the hypothesis that ACE-D and VEGF-G alleles act synergistically in association with DN, in patients with type 2 diabetes mellitus (T2DM). Patients and Methods: The VEGF (rs2010963) and ACE (rs4646994) genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 490 T2DM patients. Diabetic patients were classified as T2DM patients with and without albuminuria (control). The PCR and RFLP were used to detect the VEGF and ACE alleles. Results: A total of 255 consecutive patients with T2DM and microalbuminuria (Group A) and 235 patients with T2DM and normoalbuminuria (Group B) were included in the study. In univariate analysis, the groups were statistically similar for all variables, except for glycated hemoglobin (HbA1c) (P = 0.034), and the frequency of ACE (P = 0.015) and VEGF (P = 0.006) genotypes. Our study showed that the VEGF-G and ACE-D alleles are independently associated with the development of nephropathy. According to our data, the combination of these two risk factors had a significant synergistic effect on the risk of microalbuminuria development. Conclusions: Our study indicated that ACE-D and VEGF-G alleles can be an independent risk factor for microalbominuria in T2DM patients. © 2015, Iranian Red Crescent Medical Journal.

Style	Citing Format
MLA	Fathi M, et al.. "Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes." Iranian Red Crescent Medical Journal, vol. 17, no. 2, 2015, pp. -.
APA	Fathi M, Nikzamir AR, Esteghamati A, Nakhjavani M, Yekaninejad MS (2015). Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes. Iranian Red Crescent Medical Journal, 17(2), -.
Chicago	Fathi M, Nikzamir AR, Esteghamati A, Nakhjavani M, Yekaninejad MS. "Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes." Iranian Red Crescent Medical Journal 17, no. 2 (2015): -.
Harvard	Fathi M et al. (2015) 'Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes', Iranian Red Crescent Medical Journal, 17(2), pp. -.
Vancouver	Fathi M, Nikzamir AR, Esteghamati A, Nakhjavani M, Yekaninejad MS. Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes. Iranian Red Crescent Medical Journal. 2015;17(2):-.
BibTex	@article{ author = {Fathi M and Nikzamir AR and Esteghamati A and Nakhjavani M and Yekaninejad MS}, title = {Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes}, journal = {Iranian Red Crescent Medical Journal}, volume = {17}, number = {2}, pages = {-}, year = {2015} }
RIS	TY - JOUR AU - Fathi M AU - Nikzamir AR AU - Esteghamati A AU - Nakhjavani M AU - Yekaninejad MS TI - Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes JO - Iranian Red Crescent Medical Journal VL - 17 IS - 2 SP - EP - PY - 2015 ER -

Style

Citing Format

MLA

Fathi M, et al.. "Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes." Iranian Red Crescent Medical Journal, vol. 17, no. 2, 2015, pp. -.

APA

Fathi M, Nikzamir AR, Esteghamati A, Nakhjavani M, Yekaninejad MS (2015). Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes. Iranian Red Crescent Medical Journal, 17(2), -.

Chicago

Fathi M, Nikzamir AR, Esteghamati A, Nakhjavani M, Yekaninejad MS. "Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes." Iranian Red Crescent Medical Journal 17, no. 2 (2015): -.

Harvard

Fathi M et al. (2015) 'Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes', Iranian Red Crescent Medical Journal, 17(2), pp. -.

Vancouver

Fathi M, Nikzamir AR, Esteghamati A, Nakhjavani M, Yekaninejad MS. Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes. Iranian Red Crescent Medical Journal. 2015;17(2):-.

BibTex

@article{ author = {Fathi M and Nikzamir AR and Esteghamati A and Nakhjavani M and Yekaninejad MS}, title = {Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes}, journal = {Iranian Red Crescent Medical Journal}, volume = {17}, number = {2}, pages = {-}, year = {2015} }

RIS

TY - JOUR
AU - Fathi M
AU - Nikzamir AR
AU - Esteghamati A
AU - Nakhjavani M
AU - Yekaninejad MS
TI - Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes
JO - Iranian Red Crescent Medical Journal
VL - 17
IS - 2
SP -
EP -
PY - 2015
ER -

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