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Assessing Quality of Life in Patients With Autoimmune Bullous Diseases Using the Persian Version of Treatment of Autoimmune Bullous Disease Quality of Life Questionnaire Finds Similar Effects in Women As Men Publisher



Behkar A1, 2 ; Garmaroudi G3 ; Nasimi M1 ; Yousefi S2 ; Khosravi H4 ; Kianfar N1 ; Murrell DF5 ; Daneshpazhooh M1
Authors
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Authors Affiliations
  1. 1. Autoimmune Bullous Disease Research Center, Razi Hospital, Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Health Promotion and Education, Associate Professor of Maternal and Child Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Dermatology, University of Illinois, Chicago, IL, United States
  5. 5. Department of Dermatology at St. George Hospital, University of New South Wales, Sydney, NSW, Australia

Source: International Journal of Women's Dermatology Published:2022


Abstract

Background: In autoimmune bullous diseases (AIBDs), autoantibodies loosen molecular adhesions in the skin and/or mucosa and lead to blisters and erosions. Immunosuppressive drugs reduce mortality of the AIBD; therefore, patients will have to live longer with comorbidities. Objective: This study aims to determine the quality of life of AIBD patients undergoing systemic treatment while investigating the survey s relationship with various factors. Methods: In this 2-step cross-sectional study, we initially included 53 consecutive pemphigus patients to investigate reliability and validity of the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life (TABQOL) questionnaire. Then, we conducted the study on 119 AIBD patients, currently under treatment at an AIBD clinic in Iran. Results: The mean TABQOL score for our patients was 13.87 ± 7.51. The highest TABQOL was for epidermolysis bullosa acquisita (24 ± 8.485) followed by pemphigus foliaceus (20.5 ± 14.181) and the lowest for pemphigus vulgaris (13.24 ± 6.54). There was no significant difference between patients TABQOL scores and their gender, history of rituximab injection, and disease severity scores. We only found a positive correlation between TABQOL and prednisolone dose. Conclusion: Treatments of AIBD considerably impact the quality of life of patients and an impairment in quality of life is correlated to higher doses of prednisolone. © 2022 Elsevier Inc. All rights reserved.
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