The Correlation of Age and Gender With Parameters of 24-Hour Urinalysis in Patients With Urolithiasis Publisher



Valipour R ; Narouie B ; Jadidi S ; Siri M A ; Maleki E R
Source: Translational Research in Urology Published:2026

Abstract

Introduction Urolithiasis, a ubiquitous entity, is considered a significant burden on the healthcare system. The 24-hour urine test can significantly guide the implementation of appropriate strategies for the management of kidney stones. However, little is known about the correlation of age and gender with 24-hour urine abnormalities, notably in non-Western countries. Methods The medical records of the patients referred for urolithiasis management between 2020 and 2021 were reviewed. The results of the 24-hour urine collection were evaluated and correlated with age and gender. Results We identified 377 patients, of whom 234 (62.07 %) were male. The average age of the participants was 50.07±8.19. Those with hypocitraturia, decreased urinary output, increased creatinine, hyperoxaluria, hypomagnesuria, hyperuricosuria, as well as those who lacked hypercalciuria, were significantly younger (49.7±0.5, 41.07±0.7, 47.01±0.8, 43.3±0.3, 47.3±1.0, 47.9±0.9, 40.9±1.2, respectively; P-value<0.05; stated as age (y) ± standard error of the mean), while urinary citrate, volume, creatinine, protein, sodium, potassium, phosphorus, oxalate, and magnesium were the parameters with significant associations with gender (P-value <0.05). The most frequent urinary abnormalities were hypocitraturia (30.77 %), hypomagnesuria (29.44 %), and hyperoxaluria (28.65 %), while the increase in the urinary creatinine was the least frequent finding (7.96 %). Conclusions The current study presents the distribution of 24-hour urine abnormalities in a stone-forming population. Furthermore, certain correlations of urinary parameters with age and gender were determined, which, in turn, can be assessed in future studies to provide opportunities for designing stone risk prediction models and introducing approaches for personalized medicine. Eventually, 24-hour urine collection in patients affected by urinary calculi can be cost-effective if judiciously employed in appropriate populations. Copyright © 2026 Urology Research Center (URC), Tehran University of Medical Sciences.