Tehran University of Medical Sciences

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Development of 166Ho-Pamidronate for Bone Pain Palliation Therapy Publisher



Fakhari A1 ; Jalilian AR2 ; Yousefnia H2 ; Joharidaha F2 ; Mazidi M2 ; Khalaj A1
Authors
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Authors Affiliations
  1. 1. Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, 14155-1339, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2015


Abstract

In this work 166Ho labeled (3-amino-1-hydroxypropane-1,1-di-yl)-bis-(phosphonate) (166Ho-PMD) complex was prepared successfully at optimized conditions with acceptable radiochemical purity, stability and significant hydroxyapatite absorption. The biodistribution of 166Ho-PMD up to 48 h demonstrated significant bone uptake ratios at all time intervals but not superior to 166Ho-EDTMP. © 2014, Akademiai Kiado, Budapest, Hungary.