Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Nickel-Catalyzed Regioselective Thiolation of Anilides With Thiols Publisher



Kianmehr E1 ; Doraghi F1 ; Foroumadi A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, Tehran, 1417614411, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Synthesis (Germany) Published:2022


Abstract

An efficient method for direct thiolation of anilides with thiols using NiCl2·6H2O as the catalyst is developed. Using this method, the desired products were successfully synthesized in moderate to good yields. Initial mechanistic studies suggest that this reaction proceeds through a radical pathway. © 2022 EDP Sciences. All rights reserved.