Alcohol Consumption and Site-Specific Cancer Risk: A Comprehensive Dose-Response Meta-Analysis

Alcohol Consumption and Site-Specific Cancer Risk: A Comprehensive Dose-Response Meta-Analysis Publisher Pubmed

Bagnardi V^{1, 2} ; Rota M^{3, 4} ; Botteri E² ; Tramacere I⁵ ; Islami F^{6, 7, 8} ; Fedirko V⁹ ; Scotti L¹ ; Jenab M¹⁰ ; Turati F^{4, 11} ; Pasquali E² ; Pelucchi C⁴ ; Galeone C⁴ ; Bellocco R^{1, 12} ; Negri E⁴ Show All Authors

Bagnardi V^{1, 2}
Rota M^{3, 4}
Botteri E²
Tramacere I⁵
Islami F^{6, 7, 8}
Fedirko V⁹
Scotti L¹
Jenab M¹⁰
Turati F^{4, 11}
Pasquali E²
Pelucchi C⁴
Galeone C⁴
Bellocco R^{1, 12}
Negri E⁴
Corrao G¹
Boffetta P⁶
La Vecchia C¹³

Show Affiliations

1. Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Via Bicocca degli Arcimboldi 8, Milan, 20126, Italy
2. Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, Milan, 20141, Italy
3. Department of Health Sciences, Centre of Biostatistics for Clinical Epidemiology, University of Milan-Bicocca, Via Cadore 48, Monza, 20900, Italy
4. Department of Epidemiology, IRCCS Mario Negri Institute for Pharmacological Research, Via La Masa 19, Milan, 20156, Italy
5. Neurology, Besta Neurological Institute, Via Celoria 11, Milan, 20133, Italy
6. Tisch Cancer Institute and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029-6574, NY, United States
7. Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Science, Kargar Shomali Ave., Tehran, 14117-13135, Iran
8. Surveillance and Health Services Research, American Cancer Society, 250 Williams Street, Atlanta, 30303, GA, United States
9. Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, N.E., Atlanta, 30322, GA, United States
10. Nutritional Epidemiology Group, International Agency for Research on Cancer, 150 Cours Albert-Thomas, Lyon, 69008, France
11. Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale Tumori, Via Vanzetti, 5, Milan, 20133, Italy
12. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Box 281, Stockholm, 171 77, Sweden
13. Department of Clinical Sciences and Community Health, University of Milan, Via Vanzetti, 5, Milan, 20133, Italy

Source: British Journal of Cancer Published:2015

Abstract

Background:Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.Methods:We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity.Results:A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated.Conclusions:Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma. © 2015 Cancer Research UK. All rights reserved 0007 - 0920/15.

Related Docs

View other Related Docs

1. Dietary Fiber and Survival in Women With Breast Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies, Nutrition and Cancer (2021)

2. Alcohol Intake and Gastric Cancer: Meta-Analyses of Published Data Versus Individual Participant Data Pooled Analyses (Stop Project), Cancer Epidemiology (2018)

3. The Effect of Diabetes on the Risk of Endometrial Cancer: An Updated a Systematic Review and Meta-Analysis, BMC Cancer (2019)

4. Body Mass Index, Abdominal Adiposity, Weight Gain and Risk of Developing Hypertension: A Systematic Review and Dose–Response Meta-Analysis of More Than 2.3 Million Participants, Obesity Reviews (2018)

5. Dietary Carbohydrate and the Risk of Type 2 Diabetes: An Updated Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies, Scientific Reports (2022)

6. Occupational Exposure to Diesel Exhaust and Head and Neck Cancer: A Systematic Review and Meta-Analysis of Cohort Studies, European Journal of Cancer Prevention (2024)

7. Central Fatness and Risk of All Cause Mortality: Systematic Review and Dose-Response Meta-Analysis of 72 Prospective Cohort Studies, The BMJ (2020)

8. Association of Antibiotics Therapy During Pregnancy With Spontaneous Miscarriage: A Systematic Review and Meta-Analysis, Archives of Gynecology and Obstetrics (2020)

Experts (# of related papers)

View all Related Experts

Sakineh Shab-Bidar (41)

Kurosh Djafarian (16)

Style	Citing Format
MLA	Bagnardi V, et al.. "Alcohol Consumption and Site-Specific Cancer Risk: A Comprehensive Dose-Response Meta-Analysis." British Journal of Cancer, vol. 112, no. 3, 2015, pp. 580-593.
APA	Bagnardi V, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V, Scotti L, Jenab M, Turati F, Pasquali E, Pelucchi C, Galeone C, Bellocco R, Negri E, Corrao G, Boffetta P, La Vecchia C (2015). Alcohol Consumption and Site-Specific Cancer Risk: A Comprehensive Dose-Response Meta-Analysis. British Journal of Cancer, 112(3), 580-593.
Chicago	Bagnardi V, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V, Scotti L, et al.. "Alcohol Consumption and Site-Specific Cancer Risk: A Comprehensive Dose-Response Meta-Analysis." British Journal of Cancer 112, no. 3 (2015): 580-593.
Harvard	Bagnardi V et al. (2015) 'Alcohol Consumption and Site-Specific Cancer Risk: A Comprehensive Dose-Response Meta-Analysis', British Journal of Cancer, 112(3), pp. 580-593.
Vancouver	Bagnardi V, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V, et al.. Alcohol Consumption and Site-Specific Cancer Risk: A Comprehensive Dose-Response Meta-Analysis. British Journal of Cancer. 2015;112(3):580-593.
BibTex	@article{ author = {Bagnardi V and Rota M and Botteri E and Tramacere I and Islami F and Fedirko V and Scotti L and Jenab M and Turati F and Pasquali E and Pelucchi C and Galeone C and Bellocco R and Negri E and Corrao G and Boffetta P and La Vecchia C}, title = {Alcohol Consumption and Site-Specific Cancer Risk: A Comprehensive Dose-Response Meta-Analysis}, journal = {British Journal of Cancer}, volume = {112}, number = {3}, pages = {580-593}, year = {2015} }
RIS	TY - JOUR AU - Bagnardi V AU - Rota M AU - Botteri E AU - Tramacere I AU - Islami F AU - Fedirko V AU - Scotti L AU - Jenab M AU - Turati F AU - Pasquali E AU - Pelucchi C AU - Galeone C AU - Bellocco R AU - Negri E AU - Corrao G AU - Boffetta P AU - La Vecchia C TI - Alcohol Consumption and Site-Specific Cancer Risk: A Comprehensive Dose-Response Meta-Analysis JO - British Journal of Cancer VL - 112 IS - 3 SP - 580 EP - 593 PY - 2015 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract