Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of Olr1 Gene Polymorphisms With the Risk of Coronary Artery Disease: A Systematic Review and Meta-Analysis Publisher Pubmed



Salehipour P1 ; Rezagholizadeh F2 ; Mahdiannasser M1 ; Kazerani R3 ; Modarressi MH1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Source: Heart and Lung Published:2021


Abstract

Background: Oxidized LDL receptor 1 (OLR1) encodes LOX-1, LOXIN, and OLR1D4 transcript variants. Up-regulation of LOX-1 and down-regulation of LOXIN have an essential role in causing coronary artery disease (CAD). Discovery of risk single nucleotide polymorphisms (SNPs) in OLR1 gene is clinically important as these polymorphisms could be candidate biomarkers of CAD. Objectives: The purpose of this study is quantitative evidence synthesis on how OLR1 polymorphisms in the haplotype block impact the risk of CAD. Methods: First, a systematic keyword-based search in PubMed, Web of Science, and Scopus was conducted. After data extraction, pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for OLR1 polymorphisms and CAD. Twelve case-control studies, including 6,238 cases and 15,773 controls, were concluded in the meta-analysis. Results: Our findings demonstrate significant association of OLR1 polymorphisms in the haplotype block with CAD risk in all genetic models (allelic model: OR = 1.19, 95%CI = 1.06–1.34; additive model: OR = 1.54, 95%CI = 1.16–2.05; recessive model: OR = 1.26, 95%CI = 1.04–1.53; dominant model: OR = 1.28, 95%CI = 1.09–1.51). Subgroup analysis based on the type of polymorphism revealed that rs1050283 (3′UTR*188 C > T) and rs3736235 (IVS4-14 A > G) are more significantly associated with the risk of CAD compared to other polymorphisms in the haplotype block. Conclusions: We found a significant association between OLR1 polymorphisms in the haplotype block, especially rs1050283 and rs3736235, with CAD. We also suggest that precise determination of disease association with polymorphisms in a haplotype requires investigation of all SNPs rather than a single SNP in that specific haplotype. © 2021 Elsevier Inc.
Related Docs
View other Related Docs
1. Fish Consumption and Risk of All-Cause and Cardiovascular Mortality: A Dose-Response Meta-Analysis of Prospective Observational Studies, Public Health Nutrition (2018)
2. Plasma Levels of Brain-Derived Neurotrophic Factor in Patients With Parkinson Disease: A Systematic Review and Meta-Analysis, Brain Research (2019)
3. The Role of Thyroid Dysfunction in Alzheimer’S Disease: A Systematic Review and Meta-Analysis, Journal of Prevention of Alzheimer's Disease (2023)
4. Tim Family Gene Polymorphism and Susceptibility to Rheumatoid Arthritis: Systematic Review and Meta-Analysis, PLoS ONE (2019)
5. Trace Elements in Schizophrenia: A Systematic Review and Meta-Analysis of 39 Studies (N=5151 Participants), Nutrition Reviews (2020)
6. Dietary and Circulating Vitamin C, Vitamin E, Β-Carotene and Risk of Total Cardiovascular Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies, Public Health Nutrition (2019)
7. Inverse Association of Long-Term Nut Consumption With Weight Gain and Risk of Overweight/Obesity: A Systematic Review, Nutrition Research (2019)
8. Association Between the Dietary Inflammatory Index and the Incidence of Cancer: A Systematic Review and Meta-Analysis of Prospective Studies, Public Health (2018)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (5)
Sakineh Shab-Bidar (5)
Other Related Docs
9. Dietary Intake of Linoleic Acid, Its Concentrations, and the Risk of Type 2 Diabetes: A Systematireview and Dose-Response Meta-Analysis of Prospective Cohort Studies, Diabetes Care (2021)
10. Financial Protection Indexes and the Iranian Health Transformation Plan: A Systematic Review, Yale Journal of Biology and Medicine (2021)
11. Multidrug Resistance 1 (Mdr1/Abcb1) Gene Polymorphism (Rs1045642 C > T) and Susceptibility to Multiple Myeloma: A Systematic Review and Meta-Analysis, Hematology (2018)
12. Estimated Glucose Disposal Rate and Microvascular Complications of Diabetes Mellitus Type I: A Systematic Review and Meta-Analysis, Diabetes and Vascular Disease Research (2025)
13. Olfactory System Measurements in Covid-19: A Systematic Review and Meta-Analysis, Neuroradiology (2023)
14. Risk of Hypertension in Women With Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis and Meta-Regression, Reproductive Biology and Endocrinology (2020)
15. Association Between Magnesium Concentrations and Prediabetes: A Systematic Review and Meta-Analysis, Scientific Reports (2021)
16. Alternative Healthy Eating Index and Risk of Hip Fracture: A Systematic Review and Dose–Response Meta-Analysis, Journal of Human Nutrition and Dietetics (2019)
17. Insights Into the Role of Melatonin on the Reproductive System Toxicity Induced by Bisphenol A: A Systematic Review of Preclinical Studies, Toxin Reviews (2024)
18. Anxiety During the Covid-19 Pandemic in Hospital Staff: Systematic Review Plus Meta-Analysis, BMJ Supportive and Palliative Care (2023)
19. Selenium Deficiency After Bariatric Surgery, Incidence and Symptoms: A Systematic Review and Meta-Analysis, Obesity Surgery (2022)
20. Anti-Inflammatory Cytokines in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis, Cytokine (2019)
21. C1019t Polymorphism in the Connexin 37 Gene and Myocardial Infarction Risk in Premature Coronary Artery Disease, Journal of Tehran University Heart Center (2017)
22. Mthfr Gene Polymorphisms and Susceptibility to Myocardial Infarction: Evidence From Meta-Analysis and Trial Sequential Analysis, IJC Heart and Vasculature (2023)
23. Association of Chronic Hepatitis B Infection With Metabolic Syndrome and Its Components: Meta-Analysis of Observational Studies, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
24. The Association Between Types of Seafood Intake and the Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies, Health Promotion Perspectives (2019)
25. Intravenous Thrombolysis in Ischemic Stroke Patients With a Prior Intracranial Hemorrhage: A Meta-Analysis, Therapeutic Advances in Neurological Disorders (2022)
26. Common Molecular Markers Between Circulating Tumor Cells and Blood Exosomes in Colorectal Cancer: A Systematic and Analytical Review, Cancer Management and Research (2019)
27. Contribution of Genetic Variants in the Development of Familial Premature Coronary Artery Disease in a Cohort of Cardiac Patients, Clinical Genetics (2024)
28. A Meta-Analysis of Pro-Inflammatory Cytokines in Autism Spectrum Disorders: Effects of Age, Gender, and Latitude, Journal of Psychiatric Research (2019)
29. Carbohydrate Quantity and Quality Affect the Risk of Endometrial Cancer: A Systematic Review and Dose-Response Meta-Analysis, Clinical Nutrition (2020)
30. The Association of Neck Circumference With Risk of Metabolic Syndrome and Its Components in Adults: A Systematic Review and Meta-Analysis, Nutrition# Metabolism and Cardiovascular Diseases (2018)
31. Lipid Profile and Risk of Bone Fracture: A Systematic Review and Meta-Analysis of Observational Studies, Endocrine Research (2019)
32. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Causemortality: A Systematic Review and Dose-Responsemeta-Analysis of Prospective Observational Studies, Advances in Nutrition (2018)
33. Ultra-Processed Food and the Risk of Overweight and Obesity: A Systematic Review and Meta-Analysis of Observational Studies, International Journal of Obesity (2020)
34. Thyroid Hormone Levels in Alzheimer Disease: A Systematic Review and Meta-Analysis, Endocrine (2023)
35. Selective Reduction in Complicated Monochorionic Pregnancies: A Systematic Review and Meta-Analysis of Different Techniques, American Journal of Obstetrics and Gynecology (2022)
36. Identifying the Lowest Effective Initial Dose of Prednisolone for the Treatment of Subacute Granulomatous Thyroiditis: A Systematic Review and Meta-Analysis, Current Reviews in Clinical and Experimental Pharmacology (2022)
37. Food Insecurity and Anaemia Risk: A Systematic Review and Meta-Analysis, Public Health Nutrition (2018)
38. Dietary Sodium, Sodium-To-Potassium Ratio, and Risk of Stroke: A Systematic Review and Nonlinear Dose-Response Meta-Analysis, Clinical Nutrition (2019)
39. Gastroesophageal Reflux Disease As an Indication of Revisional Bariatric Surgery—Indication and Results—A Systematic Review and Metanalysis, Obesity Surgery (2022)
40. Cardiovascular Events Among Reproductive and Menopausal Age Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, Gynecological Endocrinology (2020)
41. A Systematic Review of the Prevalence of Anxiety Among the General Population During the Covid-19 Pandemic, Journal of Affective Disorders (2021)
42. The Association of Dietary and Urinary Sodium With Bone Mineral Density and Risk of Osteoporosis: A Systematic Review and Meta-Analysis, Journal of the American College of Nutrition (2018)