A Comparison of the Effects of Anesthesia With Ketamin-Sevoflurane and Ketamin-Propofol on Cardiorespiratory Variables in Patients Undergoing Diagnostic Cardiac Angiography at Children's Medical Center in 2014



Takzare A¹ ; Goudarzi M¹ ; Soltani AE¹ ; Tabatabaei MA¹ ; Nooralishahi B¹ Show Affiliations
Source: Revista Latinoamericana de Hipertension Published:2018

Abstract

Pediatric patients undergoing cardiac catheterization need general anesthesia with the least alteration in hemodynamic status. The aim of this study was to compare the effects of ketamine-propofol and ketamine-sevoflurane on hemodynamic changes in pediatric patients undergoing cardiac catheterization. In this randomized double-blinded clinical trial, sixty 2-8 year-old patients met the inclusion criteria and were randomly divided into two equal groups (n=30): The KS group (1 mg/kg intravenous ketamine and 2.5 minimum alveolar concentration (MAC) volatile sevoflurane for induction followed by 1.5 MAC sevoflurane which was reduced to 1 MAC after 10 min) and the KP group (0.1 ml/kg of premixed solution of 80 mg/ml ketamine and propofol for induction followed by a maintenance solution of 0.01 mg/kg min). Heart rate (HR), blood pressure, and arterial oxygen saturation were recorded and compared prior to and after the induction of anesthesia, prior to and after catheter insertion, and together with the measurement of systemic and pulmonary atrial blood pressure during angiography. Pain was recorded using Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) immediately after surgery and every 10 min until recovery and discharge. None of the patients had significant changes in blood pressure and heart rate. There was no significant difference in cardiopulmonary assessment using angiography. The mean of CHEOPS in the KS group was significantly lower than that in the KP group 40 and 50 min after surgery. There was no significant difference between the groups in terms of mean CHEOPS trend. Patients in the KS group recovered and were discharged from the recovery room faster than patients in the KP group. Based on our result, the ketamine-sevoflurane combination has no significant advantages over ketamine-propofol combination. However, its shorter recovery time has made it the preferred method of general anesthesia. © 2018 Revista Latinoamericana de Hipertension. All rights reserved.