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Metabolomics of Male Infertility: A New Tool for Diagnostic Tests



Mehrparavar B1 ; Minaitehrani A2 ; Arjmand B3, 4 ; Gilany K1, 4
Authors
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Authors Affiliations
  1. 1. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, P.O. Box: 19615-1177, Tehran, Iran
  2. 2. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  3. 3. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular Cellu Lar Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Source: Journal of Reproduction and Infertility Published:2019

Abstract

Infertility is a major health issue worldwide. Males and females contribute equally to this problem. Diagnostic semen analysis fails to identify 50% of male infertility disorders. In this regard, metabolomics as a new field of omics has been suggested to have the potential of solving and diagnosis of the male infertility problems. Metabolome has a history of around 20 years. However, there are only limited metabolomics studies carried out regarding male infertility. In this review, the current metabolomics researches that have been done in infertile men were reviewed. Based on our own results, using human seminal plasma for metabolomics studies is highly recommended to find potential biomarkers and developing diagnosis tests for detection of main deficiencies in infertile men. © 2019 Avicenna Research Institute. All rights reserved.
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