Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Breathing-Induced Errors in Quantification and Description of Dominant Intra-Prostatic Lesions (Dils) in Pet Images: A Simulation Study by Means of the 4D Ncat Phantom Publisher



Bamneshin K1, 2 ; Mahdavi SR3 ; Bitarafanrajabi A4 ; Geramifar P5 ; Hejazi P2 ; Jadidi M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Radiology Technology, Faculty of Allied Medical Sciences, Semnan University of Medical Sciences, Semnan, Iran
  2. 2. Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Nuclear Medicine, Shariati Hospital Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Radiology Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sci-ences, Tehran, Iran

Source: Journal of Biomedical Physics and Engineering Published:2022


Abstract

Background: Respiratory movement and the motion range of the diaphragm can affect the quality and quantity of prostate images. Objective: This study aimed to investigate the magnitude of respiratory-induced errors to determine Dominant Intra-prostatic Lesions (DILs) in positron emission to-mography (PET) images. Material and Methods: In this simulation study, we employed the 4D NURBS-based cardiac-torso (4D-NCAT) phantom with a realistic breathing model to simulate the respiratory cycles of a patient to assess the displacement, volume, maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), signal to noise ratio (SNR), and the contrast of DILs in frames within the respiratory cycle. Results: Respiration in a diaphragm motion resulted in the maximum superior-inferior displacement of 3.9 and 6.1 mm, and the diaphragm motion amplitudes of 20 and 35 mm. In a no-motion image, the volume measurement of DILs had the smallest percentage of errors. Compared with the no-motion method, the percentages of errors in the average method in 20 and 35 mm-diaphragm motion were 25% and 105%, respectively. The motion effect was significantly reduced in terms of the values of SU-Vmax and SUVmean in comparison with the values of SUVmax and SUVmean in no-motion images. The contrast values in respiratory cycle frames were at a range of 3.3-19.2 mm and 6.5-46 for diaphragm movements’ amplitudes of 20 and 35 mm. Conclusion: The respiratory movement errors in quantification and delineation of DILs were highly dependent on the range of motion, while the average method was not suitable to precisely delineate DILs in PET/CT in the dose-painting technique. © Journal of Biomedical Physics and Engineering.
Related Docs
1. Evaluation of Dose-Painting in the Dominant Intraprostatic Lesions by Radiobiological Parameters Using68ga-Psma Pet/Ct, Journal of Biomedical Physics and Engineering (2022)
2. The Influence of Using Different Reconstruction Algorithms on Sensitivity of Quantitative 18F-Fdg-Pet Volumetric Measures to Background Activity Variation, Iranian Journal of Nuclear Medicine (2018)
Experts (# of related papers)
Mohammad Reza Ay (1)
Parham Geramifar (1)