Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research

Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research Publisher Pubmed

Abdolahi S¹ ; Ghazvinian Z² ; Muhammadnejad S³ ; Saleh M² ; Asadzadeh Aghdaei H¹ ; Baghaei K¹

Source: Journal of Translational Medicine Published:2022

Abstract

The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations. © 2022, The Author(s).

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Style	Citing Format
MLA	Abdolahi S, et al.. "Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research." Journal of Translational Medicine, vol. 20, no. 1, 2022, pp. -.
APA	Abdolahi S, Ghazvinian Z, Muhammadnejad S, Saleh M, Asadzadeh Aghdaei H, Baghaei K (2022). Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research. Journal of Translational Medicine, 20(1), -.
Chicago	Abdolahi S, Ghazvinian Z, Muhammadnejad S, Saleh M, Asadzadeh Aghdaei H, Baghaei K. "Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research." Journal of Translational Medicine 20, no. 1 (2022): -.
Harvard	Abdolahi S et al. (2022) 'Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research', Journal of Translational Medicine, 20(1), pp. -.
Vancouver	Abdolahi S, Ghazvinian Z, Muhammadnejad S, Saleh M, Asadzadeh Aghdaei H, Baghaei K. Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research. Journal of Translational Medicine. 2022;20(1):-.
BibTex	@article{ author = {Abdolahi S and Ghazvinian Z and Muhammadnejad S and Saleh M and Asadzadeh Aghdaei H and Baghaei K}, title = {Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research}, journal = {Journal of Translational Medicine}, volume = {20}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Abdolahi S AU - Ghazvinian Z AU - Muhammadnejad S AU - Saleh M AU - Asadzadeh Aghdaei H AU - Baghaei K TI - Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research JO - Journal of Translational Medicine VL - 20 IS - 1 SP - EP - PY - 2022 ER -

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