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Pediatric Glioblastoma Multiforme in Association With Turner's Syndrome: A Case Report Publisher Pubmed



Hanaei S1 ; Habibi Z1 ; Nejat F1 ; Sayarifard F2 ; Vasei M3
Authors
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Authors Affiliations
  1. 1. Departments of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Sciences, 62 Gharib Street, Tehran, 1419733151, Iran
  2. 2. Department of Pediatric Endocrinology, Children's Hospital Medical Center, Iran
  3. 3. Department of Pathology, Digestive and Liver Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Pediatric Neurosurgery Published:2015


Abstract

The Ullrich-Turner syndrome (complete or partial X-chromosome monosomy) has been found to be associated with an increased rate of some extragonadal neoplasms. Sporadic reports of the Turner syndrome with various brain tumors, including few cases of glioblastoma multiforme, have been found in the literature. However, published data are insufficient to establish a definite relationship between these tumors and the Turner syndrome. Herein, a rare case of primary pediatric glioblastoma multiforme in a 7-year-old girl with Turner's syndrome is reported, and various aspects regarding clinical and pathophysiological issues have been discussed. Although Turner's syndrome is not one of the congenital chromosomal abnormalities which demand routine CNS screening, neurological assessment may be of value in those with relevant clinical findings. © 2015 S. Karger AG, Basel.