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Effect of Green Tea Consumption in Treatment of Mild to Moderate Depression in Iranian Patients Living With Hiv: A Double-Blind Randomized Clinical Trial Publisher



Manshadi Seyed Ali D1 ; Seyed Alireza M2 ; Mohammad Reza S1 ; Jayran Z3 ; Seyedahmad S4 ; Shams Ali R5 ; Seyed Saeid M6 ; Ali AA4
Authors
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Authors Affiliations
  1. 1. Department of Infectious Diseases and Tropical Medicine, Imam-Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, 11519, Tehran, Iran
  2. 2. Department of Infectious Diseases and Tropical Medicine, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, 11519, Iran
  3. 3. Cognitive Neuroscience Linguistics, Institute for Cognitive Science Studies (ICSS), Tehran, 11519, Iran
  4. 4. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, 11519, Iran
  5. 5. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, 11519, Iran
  6. 6. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 11519, Iran

Source: Chinese Herbal Medicines Published:2021


Abstract

Objective: Depression affects people living with HIV (PLWH) compliance leading to poor control infection. Previous observational studies showed an anti-depression effect of green tea extract (GTE). The therapeutic effect of GTE on depression were investigated in PLWH receiving antiretroviral therapy (ART). Methods: Fifty PLWH on ART with diagnose of mild to moderate of depression, participated in a double-blind, placebo-controlled trial and underwent 12 weeks of treatment with either 400 mg GTE capsules or placebo twice daily. The Hamilton depression scale of patients was measured before, 6 weeks and 12 weeks after treatment in two groups. The primary outcome measure was performed to evaluate the efficacy of GTE in improving depressive symptoms. Results: The mean of Hamilton score showed a significant difference between the two groups after 12 weeks (P = 0.035). Repeated measures ANOVA test showed a significant effect for time × treatment interaction on the Hamilton mean score between the two groups (P = 0.000). Conclusion: It seems the use of GTE capsules in PLWH on ART is safe and could lead to greater and more rapid improvement in depressive symptoms than placebo. Thus it can be considered as an alternative therapy for mild to moderate depression. Further studies with higher sample size and longer follow-up and comparisons with other antidepressive drugs are warranted. © 2020 Tianjin Press of Chinese Herbal Medicines
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