Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Utilization of Mesenchymal Stem Cells in Kidney Transplantation: From Bench to Bedside Pubmed



Saidi RF1 ; Moghadasali R2, 3 ; Shekarchian S3
Authors

Source: Iranian Journal of Kidney Diseases Published:2019


Abstract

There has been ample of preclinical and animal studies which showed efficacy and safety of using mesenchymal stem cells (MSCs) after transplantation for tissue repair, immunosuppression or tolerance induction. However, there has been a significant progress recently using MSCs in small clinical trials after transplantation. Recent results using MSCs after transplantation seem to be feasible and safe. However, there are some limitations to show the effectiveness of these cells including source, dose, timing and route of infusions. Currently, live donor kidney transplantation has been especially considered and development of recent regimes including immunosuppression drugs and MSCs administration to kidney and other organs and deceased donor transplantation would be crucial. Therefore, in this review we focused on immunomodulatory effects of MSCs that have been extensively studied to suppress various inflammatory responses in kidney transplantation. © 2019, Iranian Society of Nephrology. All rights reserved.
Related Docs
View other Related Docs
1. Mesenchymal Stem Cells: Rising Concerns Over Their Application in Treatment of Type One Diabetes Mellitus, Journal of Diabetes Research (2015)
2. Immunomodulatory Characteristics of Mesenchymal Stem Cells and Their Role in the Treatment of Multiple Sclerosis, Cellular Immunology (2015)
3. Recent Progress in Cell Therapy in Solid Organ Transplantation, International Journal of Organ Transplantation Medicine (2017)
Experts (# of related papers)
View all Related Experts
Ensieh Nasli Esfahani (2)
Bagher Larijani (2)
Other Related Docs
4. Transplant and Kidney Repair, Stem Cells in Urology (2020)
5. Immunomodulatory Activity of Human Bone Marrow and Adipose-Derived Mesenchymal Stem Cells Prolongs Allogenic Skin Graft Survival in Nonhuman Primates, Cell Journal (2021)
6. Mesenchymal Stem Cells and Natural Killer Cells Interaction Mechanisms and Potential Clinical Applications, Stem Cell Research and Therapy (2022)
7. Evaluation of Immunomodulatory Effects of Co-Culture or Supernatant of Dexamethasone or Ifn-Γ-Treated Adipose-Derived Mesenchymal Stem Cells on Spleen Mononuclear Cells, European Cytokine Network (2022)
8. The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy Via the Modulation of Inflammatory Milieu, Journal of Clinical Medicine (2019)
9. Genetically Engineered Mesenchymal Stromal Cells As a New Trend for Treatment of Severe Acute Graft-Versus-Host Disease, Clinical and Experimental Immunology (2022)
10. Immunopathology of Type 1 Diabetes and Immunomodulatory Effects of Stem Cells: A Narrative Review of the Literature, Endocrine# Metabolic and Immune Disorders - Drug Targets (2022)
11. Shining the Light on Clinical Application of Mesenchymal Stem Cell Therapy in Autoimmune Diseases, Stem Cell Research and Therapy (2022)
12. Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents, Current Medicinal Chemistry (2016)
13. Manipulated Mesenchymal Stem Cells Applications in Neurodegenerative Diseases, International Journal of Stem Cells (2020)
14. Administration of Autologous Mesenchymal Stem Cell Transplantation for Treatment of Type 1 Diabetes Mellitus, Iranian Journal of Public Health (2015)
15. Cell Therapy in Transplantation: A Comprehensive Review of the Current Applications of Cell Therapy in Transplant Patients With the Focus on Tregs, Car Tregs, and Mesenchymal Stem Cells, International Immunopharmacology (2021)
16. The Mechanisms of Cellular Crosstalk Between Mesenchymal Stem Cells and Natural Killer Cells: Therapeutic Implications, Journal of Cellular Physiology (2021)
17. Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application, Frontiers in Cell and Developmental Biology (2020)
18. Mechanisms and Potentials of Stem Cells in the Treatment of Multiple Sclerosis: The Unpaved Path, Multiple Sclerosis: A Mechanistic View (2016)
19. Interaction Between Mesenchymal Stromal Cell-Derived Extracellular Vesicles and Immune Cells by Distinct Protein Content, Journal of Cellular Physiology (2019)
20. Biological Aspects and Clinical Applications of Mesenchymal Stem Cells: Key Features You Need to Be Aware Of, Current Pharmaceutical Biotechnology (2021)