Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model

Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model Publisher

Nazari E¹ ; Khanavi M^{1, 2} ; Amani L³ ; Sharifzadeh M⁴ ; Vazirian M¹ ; Saeedi M^{2, 5} ; Sanati M⁴ ; Lamardi SNS³

Show Affiliations

1. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
2. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Traditional Pharmacy, School of Traditional persian Medicine, Tehran University of Medical Science, Tehran, Iran
4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
5. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran

Source: Pharmaceutical Sciences Published:2020

Abstract

Background: Dementia is a disease in which memory, thinking, and cognitive skills are impaired, with Alzheimer’s being the most common type of dementia. Brassica nigra is useful for eliminating memory loss in traditional Persian medicine. This study aims to examine the effect of B. nigra fixed oil (BNO) on the changes in memory caused by β-amyloid. Methods: This research was conducted on 42 Wistar rats divided into 7 groups (n=6) including 1) control (received vehicle), 2) the group receiving BNO (925 and 462.5 mg/kg), 4) sham group 5) Alzheimer group (receiving 50 ng/µl/side β-amyloid in CA1 area of hippocampus) and 2 groups receiving β-amyloid along with two different doses of BNO. The daily gavage of BNO was done 2 to 21 days post amyloid injection. The spatial memory was evaluated in Morris water maze from day 21 to 26. Results: The results of this study revealed that the gavage of BNO (925 mg/kg) to rats receiving β-amyloid, as compared to those receiving β-amyloid alone, significantly decreased the traveled distance and the required time for finding hidden platform on the training days and increased the time of presence in the target quadrant on the test days. The analysis of BNO with GC-MS revealed that Erucic acid (24.79%) and 11-Eicosenoic acid (17.23%) had the highest content in the BNO. Conclusion: Regarding the presence of unsaturated fatty acids, it is likely that the consumption of BNO can play an important role in the prevention of memory degradation which warrants further clinical studies. ©2020 The Author(s).

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Mohammad Sharifzadeh (5)

Mina Saeedi (2)

Style	Citing Format
MLA	Nazari E, et al.. "Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model." Pharmaceutical Sciences, vol. 26, no. 3, 2020, pp. 261-269.
APA	Nazari E, Khanavi M, Amani L, Sharifzadeh M, Vazirian M, Saeedi M, Sanati M, Lamardi SNS (2020). Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model. Pharmaceutical Sciences, 26(3), 261-269.
Chicago	Nazari E, Khanavi M, Amani L, Sharifzadeh M, Vazirian M, Saeedi M, Sanati M, Lamardi SNS. "Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model." Pharmaceutical Sciences 26, no. 3 (2020): 261-269.
Harvard	Nazari E et al. (2020) 'Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model', Pharmaceutical Sciences, 26(3), pp. 261-269.
Vancouver	Nazari E, Khanavi M, Amani L, Sharifzadeh M, Vazirian M, Saeedi M, et al.. Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model. Pharmaceutical Sciences. 2020;26(3):261-269.
BibTex	@article{ author = {Nazari E and Khanavi M and Amani L and Sharifzadeh M and Vazirian M and Saeedi M and Sanati M and Lamardi SNS}, title = {Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model}, journal = {Pharmaceutical Sciences}, volume = {26}, number = {3}, pages = {261-269}, year = {2020} }
RIS	TY - JOUR AU - Nazari E AU - Khanavi M AU - Amani L AU - Sharifzadeh M AU - Vazirian M AU - Saeedi M AU - Sanati M AU - Lamardi SNS TI - Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model JO - Pharmaceutical Sciences VL - 26 IS - 3 SP - 261 EP - 269 PY - 2020 ER -

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