Thermosensitive Polymer-Coated La 0.73 Sr 0.27 Mno 3 Nanoparticles: Potential Applications in Cancer Hyperthermia Therapy and Magnetically Activated Drug Delivery Systems Publisher



Soleymani M¹ ; Edrissi M¹ ; Alizadeh AM² Show Affiliations
Source: Polymer Journal Published:2015

Abstract

Thermosensitive polymer-coated La 0.73 Sr 0.27 MnO 3 (LSMO) nanoparticles with a core-shell structure were prepared as a heat-generating agent for magnetic hyperthermia therapy and magnetically activated drug delivery systems. The magnetic cores of LSMO nanoparticles with an average particle size of 54 nm were prepared using the citrate gel method. Then, the surface of the nanoparticles was successfully coated with poly(N-isopropylacrylamide-co-Acrylamide) (PNIPAAm-co-AAm) through admicellar polymerization method. First, the surfaces of the nanoparticles were coated with a bilayer surfactant containing oleic acid and SDS as an inner and outer layer surfactant, respectively. Then, the polymerization was carried out at 70 °C to enforce the adsolubilization of monomers in the hydrophobic interlayer between the two self-organized surfactants that coated each particle. The heat generation efficiency of the PNIPAAm-co-AAm-coated LSMO nanoparticles under various alternating magnetic fields was determined by induction heating analysis. The results showed that the maximum temperature attained by the nanoparticles falls within the desired therapeutic temperature range, which is suitable for cancer hyperthermia therapy and magnetically activated drug delivery systems. © 2015 The Society of Polymer Science, Japan (SPSJ) All rights reserved.