Atherogenic Index of Plasma (Aip) As a Long-Term Prognostic Factor Following Cabg: Unveiling Insights From a Large-Scale Tertiary Center Registry Analysis Publisher



Salari A¹ ; Kalhor P¹ ; Vakilibasir A^{1, 2} ; Karvane HB¹ ; Pashang M¹ ; Ghavami M¹ ; Jalali A^{2, 3} ; Alaeddini F¹ ; Masoudkabir F³ Show Affiliations
Source: Health Science Reports Published:2025

Abstract

Background and Aims: The role of the atherogenic index of plasma (AIP) in predicting major adverse cerebro-cardiovascular events (MACCE) after coronary artery bypass grafting (CABG) surgery has not been fully explored. The present study aims to investigate the prognostic value of AIP in predicting MACCE and its individual components following CABG. Methods: This is a large-scale retrospective study conducted on patients who underwent isolated CABG. The primary outcomes were all-cause mortality and MACCE, which included acute coronary syndrome (ACS), Cerebrovascular accident (CVA)/transient ischemia attack (TIA), revascularization, and all-cause mortality. Proportional Hazard (PH) Cox regression, considering stabilized Inverse probability weightings (IPW), was conducted after verifying the PH assumption. Results: Totally, 23,432 patients analyzed with median 111.4-month follow-up duration. After weighting all variables, a higher AIP was associated with a significantly increased risk of MACCE (HR = 1.05; 95% CI: 1.01–1.09; p = 0.006). Furthermore, AIP was a significant predictor of the risk of revascularization (HR = 1.15; 95% CI: 1.01–1.30; p = 0.034) and ACS (HR = 1.09; 95% CI: 1.01–1.17; p = 0.020). However, AIP couldn't be a prognostic factor for all-cause mortality and CVA. Conclusion: AIP predicts MACCE, revascularization, and ACS after CABG, serving as a readily accessible prognostic factor. © 2025 The Author(s). Health Science Reports published by Wiley Periodicals LLC.