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Association of Heavy Metals and Bio-Elements Blood Level With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies Publisher



Hasani M1 ; Khazdouz M2 ; Sobhani S3 ; Mardi P3 ; Riahi S4 ; Agh F5 ; Mahdavigorabi A9 ; Mohammadipournami S6 ; Gomnam F6, 7 ; Qorbani M3, 8
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, School of Public Health, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Ali-Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Educational Development Center, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Saveh University of Medical Sciences, Saveh, Iran
  6. 6. Student Research Committee, Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  7. 7. Department of Environmental Health, School of Health, Alborz University of Medical Sciences, Karaj, Iran
  8. 8. Department of Epidemiology and Biostatistics, School of Health, Alborz University of Medical Sciences, Karaj, Iran
  9. 9. Molecular Medicine and Genetics Research Center for Advanced Technologies in Cardiovascular Medicine Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2024


Abstract

Background and objectives: The literature has reported heavy metals might alter the physiological and biochemical functions of body organs and cause several health problems. So, the present systematic review and meta-analysis aimed to investigate the association of blood levels of essential or non-essential metals with metabolic syndrome (MetS). Methods: In this systematic review, some international databases including PubMed, Embase, Scopus, and Web of Science were searched up to February 2024. All observational studies which assessed the association of three heavy metals (cadmium, mercury, lead) and bio-elements (chromium, iron, manganese, and magnesium, copper) with the risk of MetS were included. There was no limitation in the time of publication and language. A random-effects meta-analysis was performed to estimate the pooled effect sizes. Possible sources of heterogeneity were explored by meta-regression analysis. Results: Totally, 29 studies were eligible for meta-analysis. Our results showed that increased level of cadmium (pooled OR: 1.24, 95% CI: 1.05, 1.46) and mercury (pooled OR: 1.22, 95% CI: 1.08, 1.38) significantly increased the risk of MetS. In contrast, increased level of chromium significantly reduced the risk of developing MetS (pooled OR: 0.68, 95% CI: 0.56, 0.83). Moreover, association between lead, iron, copper, magnesium, and manganese with MetS was not statistically significant (P > 0.05). However, elevated lead levels in men increased the odds of MetS. Conclusion: Our results show a significant association between blood levels of some heavy metals, including cadmium, mercury, and lead, with increased odds of MetS. On the other hand, chromium as a biometal decreased the odds of MetS. © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024.
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